Non-Polymeric Lipophilic Pharmaceutical Implant Compositions for Intraocular Use
AssigneeAlcon Inc.
InventorsJanet Howie, Eliot Slovin, David Marsh, Bhagwati Kabra
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Abstract
Solid or semi-solid intraocular implant compositions are disclosed. The compositions contain a lipophilic compound but lack a polymeric ingredient.
Claims15
An intraocular implant composition comprising 5 to 15% (w/w) of N-[4-[3-amino-1H-indazol-4-yl]phenyl]-N′-(2-fluoro-5-methoylphenyl)urea, 0.5 to 5% (w/w) of a surfactant, and 80 to 94.5% (w/w) of a lipophilic compound selected from the group consisting of glyceryl palmitostearate;
- diethylene glycol monostearate;
- propylene glycol monostearate;
- glyceryl monostearate;
- glyceryl monolinoleate;
- glyceryl monooleate;
- glyceryl monopalmitate;
- glyceryl monolaurate;
- glyceryl dilaurate;
- glyceryl monomyristate;
- glyceryl dimyristate;
- glyceryl monopalmitate;
- glyceryl dipalmitate;
- glyceryl monostearate;
- glyceryl distearate;
- glyceryl monooleate;
- glyceryl dioleate;
- glyceryl monolinoleate;
- glyceryl dilinoleate;
- glyceryl monoarachidate;
- glyceryl diarachidate;
- glyceryl monobehenate;
- and glyceryl dibehenate;
- and mixtures thereof;
- provided that the intraocular implant composition does not comprise a polymeric ingredient or an organic solvent that is miscible with or dispersible in water.
A method of treating age-related macular degeneration comprising implanting in the eye an intraocular implant composition comprising 5 to 15% (w/w) of N-[4-[3-amino-1H-indazol-4-yl]phenyl]-N′-(2-fluoro-5-methoylphenyl)-urea, 0.5 to 5% (w/w) of a surfactant, and 80 to 94.5% (w/w) of a lipophilic compound selected from the group consisting of glyceryl palmitostearate;
- diethylene glycol monostearate;
- propylene glycol monostearate;
- glyceryl monostearate;
- glyceryl monolinoleate;
- glyceryl monooleate;
- glyceryl monopalmitate;
- glyceryl monolaurate;
- glyceryl dilaurate;
- glyceryl monomyristate;
- glyceryl dimyristate;
- glyceryl monopalmitate;
- glyceryl dipalmitate;
- glyceryl monostearate;
- glyceryl distearate;
- glyceryl monooleate;
- glyceryl dioleate;
- glyceryl monolinoleate;
- glyceryl dilinoleate;
- glyceryl monoarachidate;
- glyceryl diarachidate;
- glyceryl monobehenate;
- and glyceryl dibehenate;
- and mixtures thereof;
- provided that the intraocular implant composition does not comprise a polymeric ingredient or an organic solvent that is miscible with or dispersible in water.
Dependencies are inferred from the claim text.