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US 2007/0184082 A1Published application
Biocompatible polymeric delivery systems for sustained release of quinazolinones
OwnerShlomo Magdassi, Daniel Cohninventors
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Abstract
The present invention relates to biocompatible polymeric delivery systems for controlled or sustained release of quinazolinone derivatives, including the compound halofuginone. In particular the invention relates to a polymeric delivery system comprising biocompatible polymeric beads having a two-phase core and shell structure, or polymeric films, beads or complexes that provide local sustained release of the pharmacological agent.
Claims55
A polymeric delivery system for sustained release administration of a quinazolinone derivative of formula (I)
- wherein:
- n=1-2
- R1 which may be the same or different at each occurrence is a member of the group consisting of hydrogen, halogen, nitro, benzo, lower alkyl, phenyl and lower alkoxy;
- R2 is a member of the group consisting of hydroxy, acetoxy and lower alkoxy;
- R3 is a member of the group consisting of hydrogen and lower alkenoxy-carbonyl;
- and pharmaceutically acceptable salts thereof, wherein the quinazolinone is released at a therapeutically effective dose for a period of at least one month.
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Dependencies are inferred from the claim text.