Epitope synchronization in antigen presenting cells
OwnerJohn Simard, Xiang-Dong Lei +1inventors
InventorsJohn Simard, Xiang-Dong Lei, David Diamond
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Abstract
Disclosed herein are vaccines and methods for inducing an immune response against cancer cells and cells infected with intracellular parasites. Vaccines having housekeeping epitopes are disclosed. The housekeeping epitope is formed by housekeeping proteasomes in peripheral cells, but not by professional antigen presenting cells. A vaccine containing a housekeeping epitope that is derived from an antigen associated with a peripheral target cell can thus direct an immune response against the target cell. Methods of treatment are also disclosed, which involve administering a vaccine having a housekeeping epitope.
Claims30
A composition comprising means for causing presentation, on a pAPC, of a selected peptide epitope from a first antigen associated with a first target cell, wherein the target cell normally presents a first population of class I MHC peptide epitopes on a surface thereof, and wherein the pAPC normally presents a second population of class I MHC peptide epitopes on a surface thereof, wherein the selected peptide epitope is a member of the first population, and wherein the means does not comprise a peptide of 7 to 15 amino acids or a complete antigen.
A composition comprising a first means for causing presentation, on a pAPC, of a first peptide epitope corresponding to a fragment naturally generated by proteolytic processing of a first target-associated antigen in a target cell predominantly expressing a housekeeping proteasome.
A composition comprising:
- a first sequence comprising a selected peptide epitope from a target cell, wherein the target cell normally presents a first population of class I MHC peptide epitopes on a surface thereof, and wherein the pAPC normally presents a second population of class I MHC peptide epitopes on a surface thereof, wherein the selected peptide epitope is a member of the first population;
- and
- a means for causing expression in a pAPC of said selected epitope.
Dependencies are inferred from the claim text.