Method of using abscisic acid to treat and prevent diseases and disorders
AssigneeVirginia Tech Intellectual Properties, Inc.
InventorsJosep BASSAGANYA-RIERA, Amir GURI, Raquel HONTECILLAS
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Abstract
The present invention provides compositions and methods for treating and/or preventing diseases and disorders associated with expression of PPAR γ and/or infiltration of macrophages into skeletal muscle tissue and/or white adipose tissue. The method treats such diseases and disorders with abscisic acid (ABA). Exemplary diseases and disorders include diabetes, including type 2 diabetes, prediabetes, glucose intolerance insulin resistance, and diseases and disorders involving the immune system, such as inflammation, including obesity-related inflammation, inflammatory bowel disease, type 1 diabetes, multiple sclerosis, allergies, asthma, cardiovascular disease, and arthritis.
Claims28
A method of altering the expression or activity of peroxisome proliferator-activated receptor gamma (PPAR γ) in a cell, said method comprising:
- contacting the cell with one or more of the following substances:
- abscisic acid (ABA), esters thereof, pharmaceutically suitable salts thereof, metabolites thereof, structurally related compounds thereof, and analogs thereof,
- in an amount that is sufficient to alter the expression or activity of PPAR γ in the cell.
A composition for altering the level or activity of PPAR γ in a mammalian subject, said composition comprising one or more of the following biologically active substances:
- abscisic acid, esters thereof, pharmaceutically suitable salts thereof, metabolites thereof, structurally related compounds thereof, and analogs thereof,
- in a form suitable for administration to a mammal, and in an amount sufficient to alter the level or activity of PPAR γ in the mammal.
A method of increasing insulin sensitivity and improving obesity-induced inflammation in at least one cell of a mammal, said method comprising contacting the cell with one or more of the following substances:
- abscisic acid (ABA), esters thereof, pharmaceutically suitable salts thereof, metabolites thereof, structurally related compounds thereof, and analogs thereof, in an amount that is sufficient to alter the expression or activity of PPAR γ in the cell.
Dependencies are inferred from the claim text.