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US 2007/0184057 A1Published application
Use of weak stressors to enhance the effectiveness of ionizing radiation and other treatments of disease
AssigneeThe Catholic University of America
InventorsTheodore Aaron Litovitz, Andrea Lynn Cohen, Patrick Mehl
Life of this patent
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Abstract
Enhancing the effectiveness of therapeutic ionizing radiation and other treatments of disease in which cells are to be destroyed or modified, by subjecting cells in need thereof to low-dose radiation to increase the sensitivity of the cells to subsequent subjection with a lethal dose of high dose radiation (HDR), a chemotherapeutic agent, or other type of therapeutic treatment.
Claims11
1-10. (canceled)
A method comprising the following steps:
- (a) providing sensitized cells of an individual;
- and
- (b) subjecting the sensitized cells to a therapeutic treatment that kills or modifies the functioning of at least some of the sensitized cells, wherein the level of one or more heat shock proteins in the sensitized cells are below the constitutive level of the one or more heat shock proteins for the cells.
A method comprising the following steps:
- (a) providing maximally sensitized cells of an individual;
- and
- (b) subjecting the maximally sensitized cells to a therapeutic treatment that kills or modifies the functioning at least some of the sensitized cells.
Dependencies are inferred from the claim text.