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US 2007/0184056 A1Published application
Use of weak stressors to enhance the effectiveness of ionizing radiation and other treatments of disease
AssigneeThe Catholic University of America
InventorsTheodore Litovitz, Andrea Cohen, Patrick Mehl
Life of this patent
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Abstract
Enhancing the effectiveness of therapeutic ionizing radiation and other treatments of disease in which cells are to be destroyed or modified, by subjecting cells in need thereof to low-dose radiation to increase the sensitivity of the cells to subsequent subjection with a lethal dose of high dose radiation (HDR), a chemotherapeutic agent, or other type of therapeutic treatment.
Claims11
A method comprising the following steps:
- (a) providing low dose radiation (LDR)-sensitized cells of an individual;
- and
- (b) subjecting the LDR-sensitized cells to a therapeutic treatment that kills or modifies the functioning at least some of the LDR-sensitized cells, wherein the total dose of ionizing radiation to which the LDR-sensitized cells are exposed prior to step (b) is approximately 50 cGy or less and wherein step (b) is performed within about 2 hours of the LDR-sensitized cells being exposed to the ionizing radiation.
11-20. (canceled)
Dependencies are inferred from the claim text.