Nitrophenyls and related compounds and thimerosal for the inhibition of immune related cell or tissue destruction
AssigneeCanadian Blood Services
InventorsDonald Branch, Alan Lazarus, Andrew Crow
Life of this patent
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Abstract
A method and composition for inhibiting phagocytosis of blood cells. The method involves providing a nitrophenyl compound or thimerosal with administration of the compound to a host having an auto or alloimmune disease to inhibit phagocytosis of blood cells.
Claims21
A method for inhibiting phagocytosis of blood cells, comprising:
- providing a nitrophenyl compound;
- and
- administering said compound to a host having an auto or alloimmune disease for the inhibition of said phagocytosis of blood cells.
A method for inhibiting phagocytosis of blood cells, comprising:
- providing a thimerosal compound;
- and
- administering said compound to a host having an auto or alloimmune disease for the inhibition of said phagocytosis of blood cells.
A composition for inhibiting phagocytosis of blood cells, comprising:
- p-nitrophenyl methyl disulfide.
A composition for inhibiting phagocytosis of blood cells, comprising:
- p-nitrophenylethanol.
A composition for inhibiting phagocytosis of blood cells, comprising:
- thimerosal.
A composition for inhibiting phagocytosis of blood cells, comprising:
- an immunoglobulin preparation selected from at least one of IVIg and anti-D;
- and
- a nitrophenyl compound, said preparation and said compound being present in an amount sufficient to effect inhibition of said phagocytosis.
A composition for inhibiting phagocytosis of blood cells, comprising:
- an immunoglobulin preparation selected from at least one of IVIg and anti-D;
- and
- thimerosal, said preparation and said thimerosal being present in an amount sufficient to effect inhibition of said phagocytosis.
A method for inhibiting tissue destruction due to an autoimmune disease, comprising:
- providing a nitrophenyl compound or thimerosal to a host having an autoimmune disease for the inhibition of said tissue destruction.
Dependencies are inferred from the claim text.