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US 2007/0184042 A1Published application
Method of cancer treatment by p53 protein control
AssigneeAventis Pharma S.A.
InventorsSerge Carillo, Jean-Marie Blanchard, Marc Piechaczyk
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Abstract
Method of cancer treatment by controlling cellular p53 protein levels. The invention concerns, in particular, the use of a compound capable of modulating calpaine activity.
Claims8
A method for detecting an inhibitor of p53 protein degradation comprising providing a cell extract containing one or more p53 proteins and one or more proteases, administering an inhibitor of calpain protease activity, and measuring p53 protein and p53 protein fragments.
Dependencies are inferred from the claim text.