Isolated cd4+ t cells defined by cmrf-35
AssigneeThe Corporation of the Trustees of the Order of the Sisters of Mercy in Queensland
InventorsDerek Hart, Georgina Clark
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Abstract
The present invention relates generally to a method for the treatment or prophylaxis of a condition which provokes, or is exacerbated by, an immunological response. The present invention further enables methods of diagnosis of conditions which provoke, or are exacerbated by, an immunological response. The present invention further provides therapeutic and diagnostic agents for conditions which provoke, or are exacerbated by, an immunological response. The present invention further provides compositions of cells defining a sub-population of CD4+ T cells defined by CMRF-35 and CD45RO.
Claims37
An isolated population of CD4+ T-cells wherein the population is selected from:
- CMRF-35++ CD45RO+;
- CMRF-35+ CD45RO+;
- CMRF-35− CD45RO+;
- CMRF-35+ CD45RO−;
- and
- CMRF-35− CD45RO− T-cells.
An isolated CD4+ T-cell wherein the cell is CMRF-35++ CD45RO+.
An isolated CD4+ T-cell wherein the cell is CMRF-35+ CD45RO+.
An isolated CD4+ T-cell wherein the cell is CMRF-35− CD45RO+.
An isolated CD4+ T-cell wherein the cell is CMRF-35+ CD45RO−.
An isolated CD4+ T-cell wherein the cell is CMRF-35− CD45RO−.
A method for assessing the immunological potential of a subject said method comprising obtaining a sample from said subject comprising T-cells and subjecting the sample to cell surface discrimination means to determine the presence, absence or level of CD4+ T-cells selected from the list consisting of:
- CMRF-35++ CD45RO+;
- CMRF-35+ CD45RO+;
- CMRF-35− CD45RO+;
- CMRF-35+ CD45RO−;
- and
- CMRF-35− CD45RO− T-cells.
A computer program product for assessing the presence or absence or level of a sub-population of CD4+ T-cells said product comprising:
- (i) code that receives, as input values, the identity of a reporter molecule associated with a labeled antibody which recognizes one of a CMRF-35 epitope or CD45RO marker;
- (ii) code that compares said input values with reference values to determine the level of CMRF-35 epitope or CD45RO;
- and
- (iii) a computer readable medium that stores the codes.
A computer for assessing the presence or absence or level of a sub-population of CD4+ T-cells, said computer comprises:
- (i) a machine-readable data storage medium comprising a data storage material encoded with machine-readable data, wherein said machine-readable data comprise input values which identify a reporter molecule associated with a labeled antibody which recognizes one of a CMRF-35 antibody or CD45RO marker;
- (ii) a working memory for storing instructions for processing said machine-readable data;
- (iii) a central-processing unit coupled to said working memory and to said machine readable data storage medium, for processing said machine readable data to compare said values to provide an assessment of the identity or level of CMRF-35 epitope or CD45RO;
- and
- (iv) an output hardware coupled to said central processing unit, for receiving the results of the comparison.
Dependencies are inferred from the claim text.