US 2007/0184035 A1 · ARTIFICIAL STABILIZED COMPOSITION OF CALCIUM PHOSPHATE PHASES PARTICULARLY ADAPTED FOR SUPPORTING BONE CELL ACTIVITY

Abstract

This invention relates to a bioactive artificial sintered composition for providing a morphology capable of consistently supporting bone cell activity thereon. The composition comprises stabilized calcium phosphate phases developed by the conversion of a hydroxyapatite substance in the presence of stabilizing entities at sintering temperatures into insolubilized and stabilized tricalcium phosphate. The present invention has numerous applications in medical diagnostics for the assessment of abnormal bone cell activity as well as for medical therapeutics, including bone and dental tissue replacement and repair as well as for ex vivo bone graft tissue engineering.

Claims19

Dependent claims

A bioactive artificial sintered composition for supporting bone cell activity, said composition comprising:

a powder or bulk material of stabilized insoluble tricalcium phosphate wherein the tricalcium phosphate is stabilized with stabilizing entities uniformly throughout the entire composition, and wherein said uniformly stabilized tricalcium phosphate is resorbable by osteoclasts and promotes secretion of mineralized bone matrix by osteoblasts,
wherein said stabilizing entities are selected from the group consisting of silicon entities, aluminum entities, barium entities, titanium entities, germanium entities, chromium entities, vanadium entities, niobium entities, boron entities and mixtures thereof.

Dependencies are inferred from the claim text.

Facts

Application

11/738,052Filed 20 Apr 2007

Priority

1 Sep 1995

Published

9 Aug 2007

Term ends

Not estimatedThe source records don’t support an estimate.

Classification17 codes

A61K 35/32
Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically…:…
A61L 27/12
Inorganic materials: phosphorus-containing materials, e.g. apatite
A61L 27/3821
Characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells: bone-forming cells, e.g.…
A61L 27/3895
Containing added animal cells: using specific culture conditions, e.g. stimulating differentiation of stem cells, pulsatile flow conditions

Family

Application60/003,157Us provisional application · filed 1 Sep 1995

Application08/576,238Continuation in part · filed 21 Dec 1995

Application09/029,872Continuation · filed 29 Jun 1998

Application09/029,872Continuation in part · filed 29 Jun 1998

Application11/738,052Continuation · filed 20 Apr 2007

US 2007/0184035 A1This patent

From the US filing history. Foreign family members aren’t listed.

Artificial stabilized composition of calcium phosphate phases particularly adapted for supporting bone cell activity

Life of this patent

Artificial stabilized composition of calcium phosphate phases particularly adapted for supporting bone cell activity

Life of this patent

Abstract

Claims19