Novel PEGylation agent
OwnerSoonKap Hahninventor
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Abstract
To address the issue of degradation by enzymatic reactions to proteins and peptides, polyethylene glycol (PEGylation) of the proteins and peptides has been established. PEGylated proteins and peptides have increased plasma half-lives and reduced immunogenicity. To further improve and extend the plasma half-life of desired protein or peptide therapeutics, a novel branched molecule of PEG possessing three PEGs with a single point of attachment is designed in this invention disclosure.
Claims15
A polyethylene glycol composition for use within a body for treatment of a condition, comprising:
- a triple branched polyethylene glycol molecule;
- and
- a biologically active substance.
The method of manufacturing a triple branched polyethylene glycol molecule, comprising;
- coupling a seed molecule having three amine groups and one carboxyl group with a monomethoxy-polyethylene glycol having an active group, said coupling forming a triple branched polyethylene glycol molecule.
The method of manufacturing a triple branched polyethylene glycol molecule, comprising;
- coupling a seed molecule having three amine groups and one carboxyl group with a monomethoxy-polyethylene glycol having an active group, said coupling forming a triple branched polyethylene glycol molecule;
- activating carboxyl group and coupling activated carboxyl group with a biologically active substance.
Dependencies are inferred from the claim text.