Modulation of Pathogenicity

A compound of Formula XIII, or a pharmaceutically acceptable derivative thereof:

• wherein
• A7 is independently C═O, C═S, SO2, CH—OR13, C═NR12, or CH2—CHOR13;
• A8 is independently C(R14)2, O, S, or NR12;
• A9 is independently C═O, C═S, SO2, CH—OR13, C═NR12, or CH2—CHOR13;
• m is 0, or 1;
• q is 0, or 1;
• r is 0, or 1;
• R12 is independently H, CH3, CH2—CH3, C6H5, OCH3, OCH2—CH3, OH, SH or aryl group;
• R13 is independently H, CH3, or CH2—CH3;
• R14 is independently H, alkyl, alkoxy, OH, or SH;
• A5 is a C3-C16 alkyl group optionally substituted by one or more substituents R3;
• or A5 is an aryl ring which may be substituted by one or more substituents R8, R8′ or R9,
• A6 is an aryl ring which may be substituted by one or more substituents R8, R8′ or R9,
• R3 is independently OR4, SR4, hydroxyalkyl, hydroxyalkylamino, cycloalkyl, halogen, haloalkyl, haloalkyloxy, NO2, CN, SO2NR4R5, CONR4R5, COR4, CO2R4, SO2R4, SO3R4, NR4R5, alkyl, or aryl;
• R4 is H, alkyl, cycloalkyl, aryl or heteroaryl;
• R5 is H, alkyl, aryl or heteroaryl, O-alkyl, O-aryl, or O-heteroaryl;
• and
• R8, R8′, R9 is independently methyl, ethyl, t-butyl, CN, halogen, haloalkoxy, haloalkyl, OH, alkoxy, NR4R5, or COOR4.