US 2007/0183996 A1Published application

Para-coumaric acid or para-hydroxycinnamic acid derivatives and their use in cosmetic or dermatological compositions

OwnerSabrina Okombi, Delphine Rival +3inventors

InventorsSabrina Okombi, Delphine Rival, Ahcene Boumendjel, Anne-Marie Mariotte, Eric Perrier

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Abstract

The invention relates to the use of para-coumaric acid or para-hydroxycinnamic acid derivatives in cosmetic or dermatological compositions, specifically to the use of at least one compound derived from para-coumaric acid having a general formula (I) below: in which, especially, Z represents an oxygen or an —NH— group; X and Y are identical and each represent a CH or CH2 group, as an active principle with depigmenting, free-radical-scavenging and/or antiinflammatory activity. The invention also relates to the use of the above compounds for cosmetic care or for the preparation of a pharmaceutical composition, especially for depigmenting an area of skin, having antiradical and/or antiinflammatory activity.

Claims33

Dependent claims

A topical composition comprising an effective amount of at least one compound derived from para-coumaric acid having a general formula (I) below:

in which:
Z is an oxygen or an —NH— group;
X and Y are identical and each represent a CH group or CH2 group;
n is a number ranging from 1 to 12;
Ra and Rb are identical or different and represent a hydrogen atom, a linear or branched acyl group, a linear or branched, saturated or unsaturated alkyl group;
a salified or non-salified sulfonyl group (SO3H);
or a salified or non-salified phosphonate group (PO3H2);
R1, R2, R3, R4, R5, R6, R7, and R8 are, independently of each other:
a hydrogen atom;
a hydroxyl group;
a halogen atom;
a salified or non-salified acid function;
an aldehyde function;
an amide function;
a primary, secondary, or tertiary amine function in basic or salified form;
a cyano group;
a thiol group;
a nitro group;
a sugar (O-heteroside);
a linear or branched alkoxide group;
a linear or branched alkyl chain;
a linear or branched alkenyl chain;
a linear or branched thioalkyl chain;
a linear or branched alkoxy chain;
an alkenyloxy chain;
a salified or non-salified sulfate group;
a salified or non-salified sulfonyl group;
a salified or non-salified phosphonate group;
a salified or non-salified phosphate group;
or a silanol group;
in which the carbon-based chains may be substituted;
and
a dermatologically acceptable carrier;
wherein said para-coumaric acid derivative is effective to exert a depigmenting activity, an inhibitory effect on melanogenesis, a free-radical-scavenging activity or an anti-inflamatory activity on an area of skin to which it is topically applied.

31 more elements

Dependencies are inferred from the claim text.