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US 2007/0183995 A1Published application
Compounds useful as agonists of A2A adenosine receptors, cosmetic compositions with A2A agonists and a method for using the same
AssigneeConopco, Inc., d/b/a UNILEVER
InventorsJohn Nip, Carol Bosko, Jose Rosa, Bijan Harichian, Isabel Santana
Life of this patent
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Abstract
Compounds useful as agonists of A2A adenosine receptors are described. Also described is a cosmetically acceptable composition having an agonists of A2A adenosine receptors where the composition is suitable to apply to human skin to reduce the effects of melanin, resulting in skin whitening.
Claims17
A compound comprising the formula
- wherein
- (d) each R is independently hydrogen, a C1-C20 linear, branched, substituted, unsubstituted saturated and/or unsaturated alkyl, acyl group or aryl group;
- (e) R1 is a C1-C5 alkanol or
- where each A is independently hydrogen or a C1-C5 alkyl;
- and
- (f) T is a group comprising at least on heteroatom with the provisos that T has a heteroatom selected from the group consisting of N, O and S bonded to purine and when T is
- each R and R2 are not simultaneously H when R1 is CH2OH, and when T is
- each R and R2 are not simultaneously hydrogen when R1 is
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A method for lightening skin comprising the step of contacting the skin with a composition comprising an effective amount of an agonist of A2A adenosine receptors, the effective amount being enough to lighten skin.
A composition comprising:
- (a) an agonist of A2A adenosine receptors;
- (b) a cosmetically acceptable carrier
- wherein the agonist of A2A adenosine receptors is one which results in a ΔL of at least about 0.3 when comparing three, three (3) week old Mattek Melanoderm cultures that have not been treated with the composition comprising the agonist of A2A receptors to three, three (3) week old Mattek melanoderm cultures that have been treated with the composition comprising the agonist of A2A receptors wherein treated means:
- (a) placing the melanoderm culture within a six (6) well tissue culture dish and set about 0.3 cm off of the tissue culture dish;
- (b) subjecting the melanoderm culture to a 3 micromolar composition having an agonist of A2A adenosine receptors, the composition being one prepared from a 10 millimolar solution of A2A agonist and carrier (e.g., dimethyl sulfoxide) having been diluted with Dulbecco's Modified Eagle Media;
- and
- (c) comparing the treated and untreated cultures by obtaining average L values for each with a Minolta CR-10 chromameter.
4 more elements
Dependencies are inferred from the claim text.