Fluorescein-labelled peptides
AssigneeGe Healthcare Limited
InventorsAlan Cuthbertson, Bard Indrevoll, Magne Solbakken
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Abstract
The invention relates to new peptide-based compounds and their use in diagnostic optical imaging. More specifically the invention relates to the use of such peptide-based compounds as targeting vectors that bind to receptors associated with angiogenesis. The compounds are labeled with fluorescein and may be used as contrast agents in optical imaging in diagnosis of angiogenesis-related diseases.
Claims13
A compound comprising a peptidic vector and at least one fluorescein dye, wherein the peptidic vector comprises the amino acid sequence X3-G-D, wherein the peptidic vector and the fluorescein dyes are coupled,
- and wherein
- X3 represents arginine, N-methylarginine or an arginine mimetic,
- G represents glycine,
- D represents aspartic acid,
- or a physiologically acceptable salt thereof.
Dependencies are inferred from the claim text.