Composition for ultrasound therapy and pharmaceutical liquid composition containing the same
AssigneeImarx Therapeutics, Inc.
InventorEvan Unger
Life of this patent
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Abstract
The present invention provides pharmaceutical liquid compositions, comprising a liquid, a prodrug, and a large quantity of microbubbles formed by a gas dispersed in the liquid, the microbubbles having a diameter between about 0.1 μm and 100 μm, wherein a majority of the prodrug is present outside the microbubbles. The compositions can be used for an ultrasound therapy or for enhancing effects of an ultrasound therapy. The compositions are also useful for enhancing the therapeutic effect of a prodrug, and for enhancing the therapeutic effect of ultrasound.
Claims30
A pharmaceutical liquid composition, comprising:
- (a) a liquid;
- (b) a prodrug;
- and
- (c) a plurality of microbubbles formed by a gas dispersed in the liquid, the microbubbles having a diameter between about 0.1 μm and 100 μm,
- wherein a majority of the prodrug is present outside the microbubbles, and wherein the composition is used for an ultrasound therapy or for enhancing effects of an ultrasound therapy.
A method of dosing a subject with a pharmaceutical preparation, the method comprising:
- (a) administering the pharmaceutical liquid composition of claim I to a patient in need of treatment;
- and
- (b) applying ultrasound to the pharmaceutical liquid composition, thereby dosing the subject with the pharmaceutical preparation.
A composition for enhancing the effects of ultrasound in the therapy of diseases, the composition comprising:
- (a) a liquid;
- (b) a prodrug;
- and
- (c) a plurality of microbubbles formed by a gas dispersed in the liquid, the microbubbles having a diameter between about 0.1 μm and 100 μm,
- wherein a majority of the prodrug is present outside the microbubbles and is not incorporated in the shell.
A method for enhancing the therapeutic effect of a prodrug administered to a patient, the method comprising:
- (a) administering the prodrug to the patient;
- (b) administering to the patient a liquid composition comprising a plurality of microbubbles formed by a gas dispersed in the liquid, the microbubbles having a diameter between about 0.1 μm and 100 μm;
- (b) applying ultrasound to the liquid composition and the prodrug,
- wherein a majority of the prodrug is present outside of the microbubbles, thereby enhancing the therapeutic effect of the prodrug.
A method of enhancing the therapeutic effect of ultrasound, comprising;
- (a) in a liquid containing a prodrug, fabricating microbubbles formed by a gas dispersed in the liquid, the microbubbles having a diameter between about 0.1 μm and 100 μm, wherein a majority of the prodrug is present outside of the microbubbles;
- (b) administering the liquid to a patient in need of treatment;
- and
- (b) applying ultrasound to the microbubbles,
- thereby enhancing the therapeutic effect of ultrasound.
Dependencies are inferred from the claim text.