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AssigneeOrthopeutics, L.P.
InventorThomas Hedman
Estimating the term…
A method of improving the resistance of collagenous tissue to mechanical degradation in accordance with the present invention comprises the step of contacting at least a portion of a collagenous tissue with an effective amount of a crosslinking reagent. Methods and devices for enhancing the body's own efforts to stabilize discs in scoliotic and other progressively deforming spines by increasing collagen crosslinks. This stability enhancement is caused by reducing the bending hysteresis and increasing the elasticity and bending stiffness of progressively deforming spines, by injecting non-toxic crosslinking reagents into the convex side of discs involved in the potential or progressing deformity curve. Alternatively, contact between the tissue and the crosslinking reagent is effected by placement of a time-release delivery system directly into or onto the target tissue. Methods and devices that use crosslinking agents for increasing the permeability of an intervertebral disc, improving fluid flux to the intervertebral disc, and increasing the biological viability of cells within the intervertebral disc are provided.
A method of improving the stabilization of intervertebral discs of spines subject to ongoing deforming forces, comprising the step of:
A device for improving the stabilization of intervertebral discs in situ (in the living body), comprising:
A sterile reagent and application tray enclosed in packaging with a sterile inner surface, for improving the stabilization of intervertebral discs of spines subject to ongoing deforming forces, comprising one or more of the following:
A device for increasing one or more of
A sterile reagent and application tray enclosed in packaging with a sterile inner surface, for improving or increasing one or more of
Dependencies are inferred from the claim text.