Hydroxyapaltite calcium phosphate granules, method for preparing same and uses thereof
OwnerJohn Godber, Lorraine Leiteinventors
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Abstract
The invention concerns calcium phosphates in granular form having an X-ray diffraction pattern characteristic of hydroxyapatite and good compressibility and flow properties in direct compression applications. The invention also concerns the method for preparing said granules characterized in that it consists in processing a brushite dicalcium phosphate suspension having a certain particle size distribution, using a basic solution, maintaining the pH at not less than 7.0, for a sufficient time interval to enable transformation of the brushite calcium phosphate into hydroxyapatite calcium phosphate.
Claims22
A composition comprising calcium phosphate in the form of granules having an x-ray diffraction pattern characteristic of hydroxyapatite, wherein at least 90% of the particles are larger than 10 microns and 90% of the particles are smaller than 300 microns.
6-8. (canceled)
A process for preparation of calcium phosphate granules having a hydroxyapatite x-ray diffraction pattern comprising (a) treating a brushite dicalcium phosphate suspension having a particle size such that 90% of the particles are smaller than 300 microns and 90% of them are larger than 10 microns with a basic solution, and (b) maintaining the pH of the suspension at least at 7.0, for a period of time sufficient to permit the transformation of brushite calcium phosphate into hydroxyapatite calcium phosphate.
24-33. (canceled)
Dependencies are inferred from the claim text.