Plasma detoxification and volume control system and methods of use

An extracorporeal system for the removal of cytokines and toxins from plasma and to enable the balance of plasma water comprising:

• a plasma filter for separating plasma from blood, and
• an adsorption device for removing cytokines and toxins from the plasma;
• wherein said adsorption device comprises two or more adsorbents selected from the group consisting of activated carbon, non-ionic exchange resin and ion exchange resin and wherein said adsorbents are coated with albumin prior to use, said albumin coating consisting essentially of albumin and a physiologic solution.

A method for removing toxins from blood comprising:

• circulating the venous blood of a patient through an extracorporeal circuit having an adsorptive toxin removal device disposed therein wherein said toxin removal device comprises activated carbon and two or more non-ionic resins wherein said activated carbon and said two or more non-ionic resins are coated with albumin.

A method for treating a disease or disorder in a mammal comprising:

• circulating the venous blood of a patient through an extracorporeal circuit having an adsorptive toxin removal device disposed therein wherein said adsorptive toxin removal device comprises activated carbon and two or more non-ionic resins wherein said activated carbon and said two or more non-ionic resins are coated with albumin, and
• wherein said extracorporeal circuit optionally further comprises a hemofilter.