HIV fusion inhibitor peptides with improved biological properties
AssigneeTrimeris, Inc.
InventorsJohn Dwyer, Brian Bray, Stephen Schneider, Huyi Zhang, Nicolai Tvermoes, Barbara Johnston, Paul Friedrich
Life of this patent
Estimating the term…
Abstract
Provided is an HIV fusion inhibitor peptide having an amino acid sequence of any one of SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, or SEQ ID NO:15; and provided is a pharmaceutical composition comprising a HIV fusion inhibitor peptide and one or more of a pharmaceutically acceptable carrier and macromolecular carrier, and uses and methods of treatment provided by these compositions.
Claims17
An isolated peptide comprising an amino acid sequence consisting of any one of the following:
- SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, and SEQ ID NO:15.
A method of synthesizing the peptide of SEQ ID NO:9, wherein a set of three peptide fragments are produced by solid and solution phase synthesis, the set comprising:
- (a) SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19, and a leucine residue;
- or (b) SEQ ID NO:17, SEQ ID NO:18 and SEQ ID NO:20;
- wherein the members of the set are then combined using a fragment condensation approach to produce the SEQ ID NO:9 peptide.
A set of peptides, wherein the set comprises:
- (a)
- TTWEAWDRAIAE,
- (SEQ ID NO:17)
- YAARIEALLRALQE,
- (SEQ ID NO:18)
- QQEKNEAALRE;
- (SEQ ID NO:19)
- (b)
- TTWEAWDRAIAE,
- (SEQ ID NO:17)
- YAARIEALLRALQE,
- (SEQ ID NO:18)
- QQEKNEAALREL;
- (SEQ ID NO:20)
- (c)
- TTWEAWDRAIAEYAARIEAL,
- (SEQ ID NO:29)
- LRALQEQQEKNEAALRE;
- (SEQ ID NO:30)
- (d)
- TTWEAWDRAIAEYAARIEAL,
- (SEQ ID NO:29)
- LRALQEQQEKNEAALREL;
- (SEQ ID NO:31)
- (e)
- TTWEAWDRAIA,
- (SEQ ID NO:21)
- EYAARIEALLRALQE,
- (SEQ ID NO:22)
- QQEKNEAALRE;
- (SEQ ID NO:19)
- (f)
- TTWEAWDRAI,
- (SEQ ID NO:23)
- AEYAARIEALLRALQE,
- (SEQ ID NO:24)
- QQEKNEAALRE;
- (SEQ ID NO:19)
- (g)
- TTWEAWDRA,
- (SEQ ID NO:25)
- IAEYAARIEALLRALQE,
- (SEQ ID NO:26)
- QQEKNEAALRE;
- (SEQ ID NO:19)
- (h)
- TTWEAWDR,
- (SEQ ID NO:27)
- AIAEYAARIEALLRALQE,
- (SEQ ID NO:28)
- QQEKNEAALRE;
- (SEQ ID NO:19)
- (i)
- TTWEAWDRAIA,
- (SEQ ID NO:21)
- EYAARIEALLRALQE,
- (SEQ ID NO:22)
- QQEKNEAALREL;
- (SEQ ID NO:20)
- (j)
- TTWEAWDRAI,
- (SEQ ID NO:23)
- AEYAARIEALLRALQE,
- (SEQ ID NO:24)
- QQEKNEAALREL;
- (SEQ ID NO:20)
- (k)
- TTWEAWDRA,
- (SEQ ID NO:25)
- IAEYAARIEALLRALQE,
- (SEQ ID NO:26)
- QQEKNEAALREL;
- (SEQ ID NO:20)
- (l)
- TTWEAWDR,
- (SEQ ID NO:27)
- AIAEYAARIEALLRALQE,
- (SEQ ID NO:28)
- QQEKNEAALREL;
- (SEQ ID NO:20)
- (m)
- TTWEAWDRAIAEYAARIE,
- (SEQ ID NO:32)
- ALLRALQEQQEKNEAALRE;
- (SEQ ID NO:33)
- (n)
- TTWEAWDRAIAEYAARIE,
- (SEQ ID NO:32)
- ALLRALQEQQEKNEAALREL;
- (SEQ ID NO:34)
- (o)
- TTWEAWDRAIAEYAARIEALLRALQE,
- (SEQ ID NO:40)
- QQEKNEAALRE;
- (SEQ ID NO:19)
- or
- (p)
- TTWEAWDRAIAEYAARIEALLRALQE,
- (SEQ ID NO:40)
- QQEKNEAALREL.
- (SEQ ID NO:20)
Dependencies are inferred from the claim text.