Sterically hindered poly (ethylene glycol) alkanoic acids and derivatives thereof
AssigneeNektar Therapeutics AL, Corporation
InventorsMichael Bentley, Xuan Zhao, Xiaoming Shen, Lihong Guo
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Abstract
The invention provides a sterically hindered polymer that comprises a water-soluble and non-peptidic polymer backbone having at least one terminus covalently bonded to an alkanoic acid or alkanoic acid derivative, wherein the carbon adjacent to the carbonyl group of the acid or acid derivative group has an alkyl or aryl group pendent thereto. The steric effects of the alkyl or aryl group allow greater control of the hydrolytic stability of polymer derivatives. The polymer backbone may be poly(ethylene glycol).
Claims13
A method comprising precipitating a polymer having the structure:
- wherein:
- POLY is a water-soluble and non-peptidic polymer backbone;
- R′ is a capping group;
- Q is O or S;
- M is 1 to about 20;
- Z is selected from the group consisting of alkyl, substituted alkyl, aryl and substituted aryl;
- and
- X is a leaving group,
- wherein said precipitating is effected by use of a solvent in which the polymer is essentially insoluble.
Dependencies are inferred from the claim text.