US 2007/0179191 A1Published application

Oxadiazolones and derivatives thereof as ppar delta agonists

AssigneeSanofi-Aventis Deutschland GmbH

InventorsStefanie KEIL, Wolfgang WENDLER, Maike GLIEN, Jochen GOERLITZER, Karen CHANDROSS, Daniel McGARRY, Jean MERRILL, Patrick BERNARDELLI, Baptiste RONAN, Corinne TERRIER

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Abstract

The invention relates to oxadiazolones and to their physiologically acceptable salts and physiologically functional derivatives showing PPARdelta agonist activity. What is described are compounds of the formula I, in which the radicals are as defined, and their physiologically acceptable salts and processes for their preparations. The compounds are suitable for the treatment and/or prevention of disorders of fatty acid metabolism and glucose utilization disorders as well as of disorders in which insulin resistance is involved; neurodegenerative diseases and/or demyelinating disorders of the central and peripheral nervous systems and/or neurological diseases involving neuroinflammatory processes and/or other peripheral neuropathies.

Claims31

Dependent claims

PPAR agonist compounds according to formula I:

wherein:
X is CH2 or a bond;
R1, R2, R3 and R4 are independently H, F, Cl, Br, CF3, (C1-C4) alkyl, (C0-C4) alkylene-O—(C0-C4) alkylene-H, SCH3, S(O)CH3, S(O)2CH3, CN, OCF3, OCHF2, OCH2F;
Z is a bond or CH2;
Y is O, S, S(O) or S(O)2;
W is CH2 or CH2CH2;
one of U and V is N and the other is S or O;
R5 and R6 are selected from the group consisting of (C1-C8) alkyl, (C1-C6) alkylene-O—(C0— is (C1-C6) alkyl or (C2-C6) alkenyl, where (C1-C6) alkyl can be substituted 1-2 times by Ch2OHF3, SF5, OCH3, phenyl phenyl, (C3-C6) cycloalkyl, (C2-C8) alkenyl, and where (C1-C8) alkyl or alkylenee can be substituted 1-2 times by OH or O—(C1-C4) alkyl;
alkyl, (C0-C4) alkylene-O—(C0-C4) alkylenee-H, SCF3, SF5, OCF2—CHF2, OCHF2, OCH2F, O-phenyl, phenyl, or NO2 as well as their physiologically acceptable salts, tautomeric forms and mixtures thereof.

6 more elements

Dependencies are inferred from the claim text.