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US 2007/0179185 A1Published application
New disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission
AssigneeNsab, Filial Af Neurosearch Sweden AB, Sverige
InventorsClas Sonesson, Lars Swanson, Nicholas Waters
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Abstract
The present invention relates to compounds which have therapeutic effects against disorders in the central nervous system, and in particular new 4-(ortho,meta-disubstituted phenyl)-1-alkypiperidines. wherein R1, R2, and R3 are as defined.
Claims31
1-37. (canceled)
A compound of Formula 1:
- wherein:
- R1 is selected from the group consisting of —CN, —OCF3, —OCHF2, —SCF3, —SCHF2, —CF3, F, Cl, —CH3 and —OCH3;
- R2 is selected from the group consisting of F, Cl, Br, and CH3;
- R3 is selected from the group consisting of C1-C3 alkyls and allyl,
- provided that when R1 is CN or CF3, R3 can only be C1-C2 alkyls;
- and the pharmaceutically acceptable salts thereof.
3 more elements
Dependencies are inferred from the claim text.