Novel m3 muscarinic acetylcholine receptor antagonists

A compound according to Formula I herein below:

• wherein
• When X and Y are carbons, n is 1, 2, or 3;
• m is 1, 2, or 3;
• p is 0, 1, or 2;
• When X is oxygen and Y is carbon, n is 1;
• m is 2;
• p is 1;
• When X is carbon and Y is nitrogen, n is 2;
• m is 1;
• p is 2;
• W is O, S, or NH;
• U is NR3, O, or bond;
• R3 is selected from the group consisting of hydrogen, C1-C8 branched or unbranched alkyl, C3-C8 cycloalkyl, C3-C8 cycloalkyl lower alkyl, unsubstituted or substituted phenyl, or unsubstituted or substituted phenyl C1-C3 lower alkyl;
• wherein, when substituted, a group is substituted by one or more radicals selected from the group consisting of C1-C8 alkoxy, halo, hydroxy, amino, cyano, trifluoromethyl, C1-C8 branched or unbranched alkyl, C3-C8 cycloalkyl and C3-C8 cycloalkyl lower alkyl;
• q is an integer from 0 to 7;
• h is 0, 1, or 2;
• g is 1, 2, or 3;
• V is selected from the group consisting of phenyl, thiophenyl, furanyl, pyridinyl, naphthyl, quinolinyl, indolyl, benzothiophenyl and benzofuranyl;
• R4 is selected from the group consisting of hydrogen, hydroxy, amino, halo, cyano, trifluoromethyl, C1-C8 alkoxy, C1-C8 branched or unbranched alkyl, C3-C8 cycloalkyl, C3-C8 cycloalkyl lower alkyl, phenyl, phenyl C1-C3 lower alkyl, COR6, COOR6, CONHR6, CON(R6)2, NHR6, N(R6)2, and G;
• k is an integer from 0 to 5;
• T is selected from the group consisting of an unsubstituted or substituted following group:
• mone, di, and tri substituted phenyl, thiophenyl, furanyl, pyridinyl, naphthyl, quinolinyl, indolyl, benzothiophenyl, pyrrole, thiozole, imidazole, pyrazole, triazole, oxazole, isoxazole, furazan, benzofuranyl, isoindole, indazole, carbazole, benzimidazple. Indolizine, purine, adenine, guanine, xanthine, caffeine, uric acid, azepine, pyridine, pyridazine, pyzazine, pyrimidine, triazine, pyrimidone, uracil, cytosine, thymine, isoquinoline, phthalazine, pteridine, naphthyridine, acridine, cinnoline, phenazine, quinazoline, phenoxazine, quinoxaline, phenothiazine;
• wherein, when substituted, a group is substituted by one or more radicals selected from the group consisting of C1-C8 alkoxy, halo, hydroxy, amino, trifluoromethyl, C1-C8 branched or unbranched alkyl, C3-C8 cycloalkyl, C3-C8 cycloalkyl lower alkyl, phenyl and phenyl C1-C3 lower alkyl;
• R5 is selected from the group consisting of COOR6, CONHR6, COR6, CON(R6)2, COG, unsubstituted or substituted oxadiazolyl, unsubstituted or substituted oxazolyl, unsubstituted or substituted imidazolyl, unsubstituted or substituted phenoxy, or cyano;
• wherein, when substituted, a group is substituted by one or more radicals selected from the group consisting of C1-C8 branched or unbranched alkyl, C3-C8 cycloalkyl, C3-C8 cycloalkyl lower alkyl, phenyl and phenyl C1-C3 lower alkyl, C1-C8 alkoxy, halo, hydroxy, amino, cyano and trifluoromethyl;
• G is selected from the group consisting of an unsubstituted or substituted following group:
• pyrrolidinyl, piperdinyl, dihydroindolyl, tetrohydroquinolinyl, morpholino, azetidinyl, hexahydroazepinyl, or octahydroazocinyl;
• wherein, when substituted, a group is substituted by one or more radicals selected from the group consisting of C1-C8 alkoxy, hydroxy, amino, C1-C8 branched or unbranched alkyl, C3-C8 cycloalkyl, C3-C8 cycloalkyl lower alkyl, phenyl and phenyl C1-C3 lower alkyl;
• R1is selected from the group consisting of an unsubstituted or substituted following group:
• hydrogen, phenyl, phenyl C1-C6 lower alkyl, thiophenyl, thiophenyl C1-C6 lower alkyl, furanyl, furanyl C1-C6 lower alkyl, pyridinyl, pyridinyl C1-C6 lower alkyl, imidazolyl, imidazolyl C1-C6 lower alkyl, naphthyl, naphthyl C1-C6 lower alkyl, quinolinyl, quinolinyl C1-C6 lower alkyl, indolyl, indolyl C1-C6 lower alkyl, benzothiophenyl, benzothiophenyl C1-C6 lower alkyl, benzofuranyl, benzofuranyl C1-C6 lower alkyl, benzoimidazolyl, benzoimidazolyl C1-C6 lower alkyl, C1-C8 branched or unbranched alkyl, C3-C8 cycloalkyl, C3-C8 cycloalkyl C1-C6 lower alkyl, or C3-C8 alkenyl;
• wherein, when substituted, a group is substituted by one or more radicals selected from the group consisting of C1-C8 alkoxy, phenoxy, phenyl C1-C3 alkoxy, halo, hydroxy, amino, cyano, trifluoromethyl, methylenedioxy, ethylenedioxy, propylenedioxy, butylenedioxy, C1-C8 branched or unbranched alkyl, C3-C8 cycloalkyl, C3-C8 cycloalkyl lower alkyl, phenyl, phenyl C1-C3 lower alkyl, thiophenyl, thiophenyl C1-C3 lower alkyl, furanyl, furanyl C1-C3 lower alkyl, pyridinyl, pyridinyl C1-C3 lower alkyl, naphthyl, naphthyl C1-C3 lower alkyl, quinolinyl, quinolinyl C1-C3 lower alkyl, indolyl, indolyl C1-C3 lower alkyl, benzothiophenyl, benzothiophenyl C1-C3 lower alkyl, benzofuranyl, benzofuranyl C1-C3 lower alkyl, COOH, COR6, COOR6, CONHR6, CON(R6)2, COG, NHR6, N(R6)2, G, OCOR6, OCONHR6, NHCOR6, N(R6)COR6, NHCOOR6 and NHCONHR6;
• or a pharmaceutically acceptable salt.