N-(2-phenylethyl)sulfamide derivatives as integrin alpha4 antagonists

A compound of formula (I):

• wherein:
• G is a COOH group or a tetrazolyl group;
• R1 and R2 are each independently chosen from hydrogen atoms, and alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkylalkynyl, cycloalkenyl, cycloalkenylalkyl, cycloalkenylalkenyl, cycloalkenylalkynyl, heterocyclyl, heterocyclylalkyl, heterocyclylalkenyl, heterocyclylalkynyl, aryl, arylalkyl, arylalkenyl, arylalkynyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, and heteroarylalkynyl groups;
• or R1 and R2 form, together with the nitrogen atom to which they are attached, either a 3- to 14-membered monocyclic or polycyclic heterocyclic ring system or a 5- to 14-membered heteroaryl group;
• wherein each of said 3- to 14-membered monocyclic or polycyclic heterocyclic ring system, or 5- to 14-membered heteroaryl group comprises from 1 to 5 heteroatoms chosen from nitrogen, oxygen and sulphur;
• wherein each of said alkyl, alkenyl, and alkynyl groups is independently unsubstituted or substituted with one to four substituents, wherein said one to four substituents may be the same or different and each is independently chosen from Ra;
• and wherein each of said cycloalkyl, heterocyclyl, aryl and heteroaryl groups is independently unsubstituted or substituted with one to four substituents, wherein said one to four substituents may be the same or different and each is independently chosen from Rb;
• R3 and R4 are each independently chosen from hydrogen atoms and alkyl groups having from 1 to 6 carbon atoms;
• R5 is chosen from 6- to 14-membered monocyclic or polycyclic aryl groups and 5- to 14-membered monocyclic or polycyclic heteroaryl groups comprising from 1 to 5 heteroatoms chosen from nitrogen, oxygen and sulphur;
• wherein each of said aryl and heteroaryl groups or moieties is independently unsubstituted or substituted with one to four substituents, wherein said one to four substituents may be the same or different and each is independently chosen from Rb;
• R6 is a group chosen from —OH, —ORc, —NO2, halogen, —S(O)Rc, —S(O)2Rc, —SRc, —S(O)2ORc, —S(O)NRcRc —S(O)2NRcRc, —NRcRc, —O(CRcRc)mNRcRc, —C(O)Rc, —CO2Rc, —CO2(CRcRc)mCONRcRc, —OC(O)Rc, —CN, —C(O)NRcRc, —NRcC(O)Rc, —OC(O)NRcRc, —NRcC(O)ORc, —NRcC(O)NRcRc, —CRc(N—ORc), —CFH2, —CF2H, —Ra, —CF3, alkyl, alkenyl and alkynyl;
• n is an integer from 0 to 3
• Ra is a group chosen from alkyl, —OH, —ORc, —NO2, halogen, —S(O)Rc, —S(O)2Rc, —SRc, —S(O)2ORc, S(O)NRcRc, —S(O)2NRcRc, —NRcRc, —O(CRcRc)mNRcRc, —C(O)Rc, —CO2Rc, —CO2(CRcRc)mCONRcRc, —OC(O)Rc, —CN, —C(O)NRcRc, —NRcC(O)Rc, —OC(O)NRcRc, —NRcC(O)ORc, —NRcC(O)NRcRc, —CRc(N—ORc), —CFH2, —CF2H, —Ra, and —CF3;
• wherein if two or more Rc groups are present these Rc groups may be the same or different;
• Rb is a group chosen from —OH, —ORd, —NO2, halogen, —S(O)Rd, —S(O)2Rd , —SRd, —S(O)2ORd, —S(O)NRdRd, —S(O)2NRdRd, —NRdRd, —O(CRdRd)mNRdRd, —C(O)Rd, —CO2Rd, —CO2(CRdRd)mCONRdRd, —OC(O)Rd, —CN, —C(O)NRdRd, —NRdC(O)Rd, —OC(O)NRdRd, —NRdC(O)ORd, —NRdC(O)NRdRd, —CRd(N—ORd), —CFH2, —CF2H, —Ra, —CF3, alkyl, alkenyl, C2-4alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroaryl and heteroarylalkyl;
• wherein each of said alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl groups is independently unsubstituted or substituted with one to four substituents;
• wherein said one to four substituents may be the same or different and each is independently chosen from Ra;
• L1 is either a direct bond or a group chosen from N(Rc)-, —O—, —N(Rc)CO—, —CON(Rc)-, —O(CO)N(Rc)- and —N(Rc)(CO)O—;
• Rc is a hydrogen atom or an alkyl group having from 1 to 4 carbon atoms;
• Rd is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkylalkynyl, cycloalkenyl, cycloalkenylalkyl, cycloalkenylalkenyl, cycloalkenylalkynyl, heterocyclyl, heterocyclylalkyl, heterocyclylalkenyl, heterocyclylalkynyl, aryl, arylalkyl, arylalkenyl, arylalkynyl, heteroaryl, heteroarylalkyl, heteroarylalkenyl, or heteroarylalkynyl;
• wherein each of said alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, heterocyclyl, aryl and heteroaryl groups is independently unsubstituted or substituted with one to four substituents;
• wherein said one to four substituents may be the same or different and each is independently chosen from Re;
• Re is a group chosen from alkyl, —OH, —ORc, —NO2, halogen, —S(O)Rc, —S(O)2Rc, —SRc, —S(O)2ORc, —S(O)NRcRc, —S(O)2NRcRc, —NRcRc, —O(CRcRc)mNRcRc, —C(O)Rc, —CO2Rc, —CO2(CRcRc)mCONRcRc, —OC(O)Rc, —CN, —C(O)NRcRc, —NRcC(O)Rc, —OC(O)NRcRc, —NRcC(O)ORc, —NRcC(O)NRcRc, —CRc(N—ORc), —CFH2, —CF2H, —Ra, or —CF3;
• wherein if two or more Rc groups are present these Rc groups may be the same or different;
• or pharmaceutically acceptable salt thereof;
• or, when G is a carboxylic group in a compound of formula (I) or in a pharmaceutically acceptable salt of a compound of formula (I), a compound resulting from the esterification, with an alcohol, of said carboxylic group;
• or a pharmaceutically acceptable salt thereof.