Aryl-isoxazol-4-yl-imidazo[1,2-a]pyridine derivatives

An aryl-isoxazol-4-yl-imidazo[1,2-a]pyridine derivative of formula I

• wherein
• R1 is hydrogen, halogen, hydroxy, lower alkyl, benzyloxy or —O—(CH2)—(CO)-5 or 6 membered heteroaryl optionally substituted by aryl or by lower alkyl;
• R2 is hydrogen, halogen, lower alkyl, lower alkynyl, amino, —NHC(O)—Ra or —(CO)—Ra;
• R3 is hydrogen, halogen, cyano, lower alkyl, lower alkynyl, amino, —NHC(O)—Ra, —(CO)—Ra, -5 or 6-membered heterocycloalkyl in the 1-position, optionally substituted by ═O or is a -5 or 6-membered heteroaryl in the 1-position;
• R4 is hydrogen or -5 or 6-membered heteroaryl;
• R5 is lower alkyl or cycloalkyl;
• Ra is lower alkoxy or NR′R″, wherein R′ and R″ are each independently hydrogen, lower alkyl optionally substituted by hydroxy, lower alkynyl, —(CH2)n-cycloalkyl, —(CH2)n-5 or 6-membered heterocycloalkyl or —(CH2)n-5 or 6-membered heteroaryl;
• and
• n is 0 to 3;
• or a pharmaceutically acceptable acid addition salt thereof.