Back to results
US 2007/0179174 A1Published application
Methods and compositions for slowing aging
OwnerSergei Bachurin, Vladimir Grigorievinventors
Life of this patent
Estimating the term…
Abstract
The present invention provides a pharmacological agent based on derivatives of hydrogenated pyrido (4,3-b) indoles and uses thereof. Specifically, the invention provides a geroprotector in the series of hydrogenated pyrido (4,3-b) indoles (several derivatives), which can be used for slowing aging, prolonging lifespan of an individual or cells in an individual, and/or improving quality of life of an individual developing or having a risk of developing age-associated manifestations and/or pathologies.
Claims24
1:
- A method selected from the group consisting of:
- (1) slowing aging in a mammal, the method comprising administering to a mammal an amount of a hydrogenated pyrido (4,3-b) indole or pharmaceutically acceptable salt thereof effective to slow aging;
- (2) slowing the progression of age associated hair loss in a mammal, the method comprising administering to a mammal an amount of a hydrogenated pyrido (4,3-b) indole or pharmaceutically acceptable salt thereof effective to slow the progression of age associated hair loss;
- (3) slowing the progression of age associated weight loss in a mammal, the method comprising administering to a mammal an amount of a hydrogenated pyrido (4,3-b) indole or pharmaceutically acceptable salt thereof effective to slow the progression of age associated weight loss;
- (4) slowing the onset of an age associated vision disturbance in a mammal, the method comprising administering to a mammal an amount of a hydrogenated pyrido (4,3-b) indole or pharmaceutically acceptable salt thereof effective to slow the onset of an age associated vision disturbance;
- (5) prolonging the lifespan of a mammal, the method comprising administering to a mammal an amount of a hydrogenated pyrido (4,3-b) indole or pharmaceutically acceptable salt thereof effective to prolong the lifespan of the mammal;
- and (6) improving the quality of life of a mammal, the method comprising administering to a mammal an amount of a hydrogenated pyrido (4,3-b) indole or pharmaceutically acceptable salt thereof effective to improve the quality of life of the mammal.
4 more elements
2:
- The method of claim 1, wherein the hydrogenated pyrido (4,3-b) indole is a tetrahydro pyrido (4,3-b) indole.
3:
- The method of claim 1, wherein the hydrogenated pyrido (4,3-b) indole is a hexahydro pyrido (4,3-b) indole.
4:
- The method of claim 1, wherein the hydrogenated pyrido (4,3-b) indole is of the formula:
- wherein:
- R1 is selected from a lower alkyl or aralkyl
- R2 is selected from a hydrogen, aralkyl or substituted heteroaralkyl
- R3 is selected from hydrogen, lower alkyl or halo.
2 more elements
5:
- The method of claim 2, wherein aralkyl is PhCH2— and substituted heteroaralkyl is 6-CH3-3-Py-(CH2)2—.
6:
- The method of claim 2, wherein
- R1 is selected from CH3—, CH3CH2—, or PhCH2—
- R2 is selected from H—, PhCH2—, or 6-CH3-3-Py-(CH2)2—
- R3is selected from H—, CH3— or Br—.
1 more element
7:
- The method of claim 1, wherein the hydrogenated pyrido (4,3-b) indole is selected from the group consisting of:
- cis(±) 2,8-dimethyl-2,3,4,4a,5,9b-hexahydro- 1 H-pyrido[4,3-b]indole;
- 2-ethyl-2,3,4,5-tetrahydro-1H-pyrido [4,3-b]indole;
- 2-benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole;
- 2,8-dimethyl-5-benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole;
- 2-methyl-5-(2-methyl-3-pyridyl)ethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole;
- 2,8-dimethyl-5-(2-(6-methyl-3-pyridyl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido [4,3-b]indole;
- 2-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole;
- 2,8-dimethyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole;
- 2-methyl-8-bromo-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole.
7 more elements
8:
- The method of claim 7, wherein the hydrogenated pyrido (4,3-b) indole is 2,8-dimethyl-5-(2-(6-methyl-3-pyridyl)ethyl)-2,3,4,5-etrahydro-1H-pyrido[4,3-b]indole.
9:
- The method of claim 1 or 8, wherein the pharmaceutically acceptable salt is a pharmaceutically acceptable acid salt.
10:
- The method of claim 9, wherein the pharmaceutically acceptable salt is a hydrochloride acid salt.
11:
- The method of claim 1, wherein the hydrogenated pyrido (4,3-b) indole is 2,8-dimethyl-5-(2-(6-methyl-3-pyridyl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole dihydrochloride.
12:
- The method of claim 6, wherein R1 is CH3—, R2 is H and R3 is CH3—.
13:
- The method of claim 6, wherein R1 CH3CH2— or PhCH2—, R2 is H—, and R3 is CH3—.
14:
- The method of claim 6, wherein R1 is CH3—, R2is PhCH2—, and R3is CH3—.
15:
- The method of claim 6, wherein R1 is CH3—, R2is 6-CH3-3-Py-(CH2)2—, and R3 is H—.
16:
- The method of claim 6, where R2 is 6-CH3-3-Py-CH2)2—.
17:
- The method of claim 6, wherein R1 is CH3—, R2is H—, and R3is H— or CH3—.
18:
- The method of claim 6, where R1 is CH3—, R2 is H—, and R3is Br—.
19-132. (canceled)
133:
- A sustained release formulation comprising a compound of the formula:
- wherein:
- R1 is selected from CH3—, CH3CH2—, or PhCH2—
- R2 is selected from H—, PhCH2—, or 6-CH3-3-Py-(CH2)2—
- R3 is selected from H—, CH3— or Br—,
- or a pharmaceutically acceptable salt thereof.
3 more elements
134:
- A sustained release device comprising a compound of the formula:
- wherein:
- R1 is selected from CH3—, CH3CH2—, or PhCH2—
- R2 is selected from H—, PhCH2—, or 6-CH3-3-Py-(CH2)2—
- R3 is selected from H—, CH3— or Br—,
- or a pharmaceutically acceptable salt thereof.
3 more elements
135:
- The sustained release formulation of claim 133, wherein the compound is 2,8-dimethyl-5-(2-(6-methyl-3-pyridyl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole or a pharmaceutically acceptable salt thereof.
136:
- The sustained release device of claim 134, wherein the compound is 2,8-dimethyl-5-(2-(6-methyl-3-pyridyl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole or a pharmaceutically acceptable salt thereof.
137:
- A kit comprising 2,8-dimethyl-5-(2-(6-methyl-3pyridyl)ethyl)-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole or a pharmaceutically acceptable salt thereof and instructions for use.