Cyclic compounds

A compound represented by the formula:

• A-W—Ar (I)
• wherein, A is a group represented by the formula (A1) or (A2):
• wherein, ring Aa is a 5- or 6-membered ring which may have one or two further heteroatoms selected from oxygen, sulfur and nitrogen at a position other than Q and X, and may be further substituted with one or more substituents in addition to R1;
• ring Ab is a 5- or 6-membered ring which may have one or two further heteroatoms selected from oxygen, sulfur and nitrogen at a position other than Y1, Y2 and X, and may be further substituted with one or more substituents in addition to R1;
• ring Ac is a 5- or 6-membered ring which may have one or two further heteroatoms selected from oxygen, sulfur and nitrogen at a position other than Y1, Y2 and Q. and may be substituted with one or more substituents;
• R1 is an optionally substituted hydrocarbyl, a substituted amino, an optionally substituted cyclic amino, a substituted hydroxy, a substituted sulfanyl, an optionally substituted sulfinyl, or an optionally substituted sulfonyl;
• X is carbonyl, —O—, —S—, —SO—, or —SO2—;
• Y1, Y2 and Q are independently optionally substituted carbon or nitrogen;
• is a single or double bond;
• W is a bond, an optionally substituted methylene, an optionally substituted ethylene, an optionally substituted imino, —O—, —S—, —SO—, or —SO2—;
• Ar is an optionally substituted aryl or an optionally substituted heteroaryl;
• provided that when the group represented by the formula (A2) is a group represented by the formula:
• wherein R′ is hydrogen, chloro or an optionally substituted alkoxy and R1 is as defined above;
• and W is a bond, then Ar is not thiazolyl substituted with one or two substituents or condensed with dihydroimidazole;
• and exluding the following compounds:
• (i) a compound represented by the formula:
• wherein Ra is a substituted carbamoyl,
• (ii) a compound represented by the formula:
• wherein Rd1 and Rd3 is each hydrocarbyl, Rd2 and Rd4 is each carboxy optionally substituted with hydrocarbyl,
• (iii) a compound represented by the formula:
• wherein Rb is hydrogen, amino or phenyl, Rc is C1-4 alkyl, a substituted phenyl or an optionally substituted heteroaryl,
• (iv) ethyl 4-(6-chloro-2,2,4-trimethyl-3,4-dihydro-2H-1,4-benzoxazin-8-yl)-6-propyl-2,4-dihydro-1H-pyrazolo[3,4-b]pyridine-5-carboxylate, 7-methoxy-3-(4-methoxyphenyl)-1-methyl-5-phenylquinolin-4(1H)-one, 8-methoxy-3-(4-methoxyphenyl)-1-methyl-5-phenylquinolin-4(1H)-one, 4-(8-benzyl-4-methyl-3,4-dihydro-2H-1,4-benzoxazin-6-yl)-2,4-dioxobutanoic acid, ethyl 1,7-dimethyl-4-oxo-3,5-diphenyl-1,2,3,4-tetrahydroquinazoline-6-carboxylate, 1-cyclobutyl-6,8-difluoro-7-(4-methylpiperazin-1-yl)-4-oxo-5-phenoxy-1,4-dihydroquinoline-3-carboxylic acid, 1-cyclopropyl-7-(2,6-dimethylpyridin-4-yl)-6,8-difluoro-4-oxo-5-(phenylthio)-1,4-dihydroquinoline-3-carboxylic acid, 1-ethyl-8-methoxy-5-phenylquinolin-4(1H)-one, 1-cyclopropyl-6,8-difluoro-7-(4-methylpiperazin-1-yl)-4-oxo-5-(phenylthio)-1,4-dihydroquinoline-3-carboxylic acid, 4,6-dimethyl-8-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)-2H-1,4-benzoxazin-3(4H)-one, 4,6-dimethyl-8-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)-2H-1,4-benzoxazin-3(4H)-one, 2,2,4-trimethyl-8-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)-2H-1,4-benzoxazin-3(4H)-one, 8-chloro-1-methyl-4-oxo-5-phenyl-1,4-dihydroquinoline-3-carboxylic acid, 8-[(4,6-dimethoxypyrimidin-2-yl)sulfinyl]-4-methyl-2-phenylphthalazin-1(2H)-one, 3-[(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amino]-6-methyl-1,7-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, 6-(4-bromophenyl)-1-(4-methoxyphenyl)-5-methyl-7-oxo-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3-carbonitrile, 3,6-dibenzyl-1-cyclopentyl-1,7-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, methyl (6-tert-butoxy-4-oxo-1,3-diphenyl-1,4-dihydro-5H-pyrazolo[3,4-d]pyrimidin-5-yl)acetate, 1,3,6-trimethyl-5-phenyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione, ethyl 4-({2-[(2,2-dimethylpropanoyl)amino]-6-methyl-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl}thio)benzoate and methyl 4-{2-[2-amino-7-benzyl-3-(isopropoxymethyl)-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl]vinyl}benzoate;
• or a salt thereof.