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US 2007/0179160 A1Published application
Use of rnai inhibiting parp activity for the manufacture of a medicament for the treatment of cancer
AssigneeThe University of Sheffield
InventorThomas Helleday
Life of this patent
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Abstract
The present invention relates to the use of an agent that inhibits the activity of an enzyme that mediates repair of a DNA strand break in the manufacture of a medicament for the treatment of diseases caused by a defect in a gene that mediates homologous recombination.
Claims32
1-32. (canceled)
A method of treatment of a disease caused by a defect in a gene that mediates homologous recombination in a mammal, the method comprising;
- administering to the mammal a therapeutically effective amount of an agent that inhibits the activity of an enzyme that mediates repair of DNA strand breaks.
A method for inducing apoptosis in HR defective cells in a mammal, the method comprising;
- administering to the mammal a therapeutically effective amount of a PARP inhibitor.
Dependencies are inferred from the claim text.