Compounds for the treatment of proliferative disorders

A method of treating or preventing a proliferative disorder in a subject, comprising administering to the subject an effective amount of a compound represented by formula (I):

• or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein:
• one of Ra or Rb is —H and the other is an optionally substituted aryl or an optionally substituted heteroaryl;
• and
• R2 is an optionally substituted aryl or an optionally substituted heteroaryl, provided that R2 is not an unsubstituted phenyl.

A method of blocking, occluding, or otherwise disrupting blood flow in neovasculature, comprising contacting the neovasculature with an effective amount of a compound represented by formula (I):

• or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein:
• one of Ra or Rb is —H and the other is an optionally substituted aryl or an optionally substituted heteroaryl;
• and
• R2 is an optionally substituted aryl or an optionally substituted heteroaryl, provided that R2 is not an unsubstituted phenyl.

A method of treating or preventing macular degeneration in a subject, comprising administering to the subject an effective amount of a compound represented by formula (I):

• or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein:
• one of Ra or Rb is —H and the other is an optionally substituted aryl or an optionally substituted heteroaryl;
• and
• R2 is an optionally substituted aryl or an optionally substituted heteroaryl, provided that R2 is not an unsubstituted phenyl.

A compound represented by formula (I):

• or a pharmaceutically acceptable salt, solvate, clathrate, and prodrug thereof, wherein:
• one of Ra or Rb is —H and the other is an optionally substituted aryl or an optionally substituted heteroaryl;
• and
• R2 is an optionally substituted aryl or an optionally substituted heteroaryl, provided that R2 is not an unsubstituted phenyl.

A compound represented by formula (IA):

• or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein:
• one of Ra or Rb is —H and the other is an optionally substituted aryl or an optionally substituted heteroaryl;
• and
• Rx is (Raa)m, —Raa—C(O)(CH2)nC(O)OH, —C(O)(CH2)nC(O)OH, —C(O)YRz, —C(O)NH—Raa, or (Raa)qC(O)(Y1);
• Ry is —H or lower alkyl;
• Rw is —H, an alkyl, an alkenyl, an alkynyl, cyano, a haloalkyl, an alkoxy, a haloalkoxy, a halo, an amino, an alkylamino, a dialkylamino, —OP(O)(OR7)2, —SP(O)(OR7)2, nitro, an alkyl ester, or hydroxyl;
• R7, for each occurrence, is independently —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl;
• Raa is an amino acid residue or an amino acid residue analog;
• Y is CH2, O, or NH;
• Rz is Alk-NH2, Alk-C(O)OH, Het, or Y1;
• Alk is an optionally substituted alkylene;
• Het is an optionally substituted heteroalkyl;
• Y1 is a water soluble polymer with a molecular weight less than 60,000 daltons;
• n is 1, 2, 3, or 4;
• m is an integer from 1 to 10;
• and
• q is 0 or 1.

A compound represented by formula (IB):

• or a pharmaceutically acceptable salt, solvate, clathrate, or prodrug thereof, wherein:
• one of Ra or Rb is —H and the other is an optionally substituted aryl or an optionally substituted heteroaryl;
• and
• Rw is —H, an alkyl, an alkenyl, an alkynyl, cyano, a haloalkyl, an alkoxy, a haloalkoxy, a halo, an amino, an alkylamino, a dialkylamino, —OP(O)(OR7)2, —SP(O)(OR7)2, nitro, an alkyl ester, or hydroxyl;
• and
• R7, for each occurrence, is independently —H, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted cycloalkenyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted aralkyl, or an optionally substituted heteraralkyl.