N-phenyl-piperazine derivatives and methods of prophylaxis or treatment of 5ht2c receptor associated diseases

A compound of Formula (I):

• wherein:
• R1 is H or C1-8 alkyl;
• R2 is C2-4 alkenyl, C1-4 alkyl or C1-4 haloalkyl;
• and
• R3, R4, R5, R6 and R7 are each independently H, C1-4 acyl, C1-4 acyloxy, C1-4 acylthioxy, C2-4 alkenyl, C1-4 alkoxy, C1-4 alkyl, C1-4 alkylcarboxamido, C1-4 alkylsulfinyl, C1-4 alkylsulfonamide, C1-4 alkylsulfonyl, C1-4 alkylthio, amino, C1-4 alkylamino, carbo-C1-4-alkoxy, carboxamide, cyano, C2-6 dialkylamino, C1-4 haloalkoxy, C1-4 haloalkyl, C1-4 haloalkylsulfinyl, C1-4 haloalkylsulfonyl, C1-4 haloalkylthio, halogen, hydroxyl, phenyl, and thiol;
• or
• a pharmaceutically acceptable salt, hydrate and solvate thereof;
• provided that the compound is not 1-(4-Chloro-phenyl)-2-methyl-piperazine;
• 1-(3,5-Difluoro-phenyl)-2-methyl-piperazine;
• 2-Methyl-1-(2-methylsulfanyl-phenyl)-piperazine;
• 4-Amino-3-fluoro-2-(2-methyl-piperazin-1-yl)-5-nitro-benzonitrile;
• 2-Methyl-1-phenyl-piperazine;
• 4-(2-Isopropyl-piperazin-1-yl)-2-trifluoromethyl-benzonitrile;
• 4-(2-Ethyl-piperazin-1-yl)-2-trifluoromethyl-benzonitrile;
• 4-(2-Methyl-piperazin-1-yl)-2-trifluoromethyl-benzonitrile;
• 1-(3-Chloro-phenyl)-2-methyl-piperazine;
• 2-Methyl-1-m-tolyl-piperazine;
• 4-(2-Methyl-piperazin-1-yl)-benzamide;
• 1-(2-Fluoro-phenyl)-2-methyl-piperazine;
• 4-(2-Methyl-piperazin-1-yl)-phenol;
• 1-(3-Methoxy-phenyl)-2-methyl-piperazine;
• 2-Methyl-1-(3-trifluoromethyl-phenyl)-piperazine;
• 1-(4-Methoxy-phenyl)-2-methyl-piperazine;
• 2-Methyl-1-p-tolyl-piperazine;
• 2,4-Dimethyl-1-phenyl-piperazine;
• 4-Chloro-5-(4-ethyl-2-methyl-piperazin-1-yl)-benzene-1,2-diamine;
• 4-Chloro-5-(4-ethyl-2-methyl-piperazin-1-yl)-2-nitro-phenylamine;
• 5-(4-Ethyl-2-methyl-piperazin-1-yl)-2-nitro-4-trifluoromethyl-phenylamine;
• and 5-(4-Ethyl-2-methyl-piperazin-1-yl)-4-methyl-2-nitro-phenylamine.