Isoquinoline aminopyrazole derivatives

Compounds of formula I and all pharmaceutically acceptable salts or esters thereof wherein formula I is:

• wherein:
• (a) R1 is hydrogen, alkyl or cycloalkyl;
• (b) R2 is hydrogen or alkyl;
• (c) R3 is selected from the group consisting of:
• (1) unsubstituted alkyl,
• (2) alkyl which is substituted one or two times with —C(O)O-alkyl, heteroaryl, phenyl, heterocyclyl or cycloalkyl,
• (3) alkyl wherein one or more —CH2-groups are replaced by oxygen,
• (4) aryl which is optionally substituted one or more times with halogen, alkyl, halogenated alkyl, halogenated alkoxy, cyano, —C(O)-alkyl, —NH—C(O)-alkyl, —C(O)OH, —C(O)O-alkyl, unsubstituted alkoxy, alkoxy substituted by heterocyclyl, or —NR2,
• (5) heteroaryl which is optionally substituted one or more times with alkyl,
• (6) cycloalkyl, and
• (7) heterocyclyl;
• (d) R3a is hydrogen, alkyl or alkoxy;
• (e) R4 is hydrogen, alkyl, alkoxy, halogen, cyano, —C(O)NR2,
• —(CH2)n—Y—R7 or -Z-R8;
• (f) R5 is hydrogen, alkyl, alkoxy, halogen, cyano, —C(O)NR2, —(CH2)n—Y—R7 or -Z-R8;
• and R6 is hydrogen, alkyl, alkoxy, halogen or cyano;
• or alternatively R5 and R6 form together with the carbon atoms to which they are attached a 5- or 6-membered heterocyclic ring;
• (g) X is a single bond, —NR—, —O—, —S—, —C(O)— or —C(O)NR—;
• (h) Y is —O—, —NR—, —S—, —S(O)2NR—, —NRC(O)—, —NRC(O)O— or —C(O)NR—;
• (i) Z is —C(O)—, —O—, a single bond or alkylene;
• (j) R7 is cycloalkyl;
• or alkyl, which is optionally substituted one or more times by alkoxy, hydroxy, alkylsulfonyl, heterocyclyl or —NR2;
• (k) R8 is heterocyclyl;
• (l) R is hydrogen or alkyl;
• and
• (m) n is 0, 1, 2 or 3.