Piperazinyl derivatives as modulators of chemokine receptor activity

A compound of Formula (I):

• or a stereoisomer or prodrug or pharmaceutically acceptable salt from thereof, wherein:
• T is absent,
• W is —CHR3a—, —CHR3aCHR3b— or cycloalkyl;
• R1 is alkyl, cycloalkyl, aryl, heterocyclyl or heteroaryl, all of which may be optionally substituted with 0-5 R1a;
• R1a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH2, —CN, —NO2, —C(═O)OH, —C(═O)O(CR8R8)rR10, —O(CF2)rCF3, —O(CR8R8)rR10, —OH, —SH, —S(CR8R8)rR10, —S(O)3H, —P(O)3H2, —C(═O)NR9R9, —NR9R9, —S(O)2NR9R9, —NR9S(O)2(CF2)rCF3, —C(═O)NR9S(O)2R6, —S(O)2NR9C(═O)OR6, —S(O)2NR9C(═O)NR9R9, —C(═O)NR9S(O)2(CF2)rCF3, —C(═O)(CR8R8)rR10, —NR9C(═O)H, —NR9C(═O)(CR8R8)rR10, —OC(═O)(CR8R8)rR10, —C(═NR14)NR9R9, —NHC(═NR14)NR14R14, —S(═O)(CR8R8)rR10, —S(O)2(CR8R8)rR10, —NR9C(═O)OR8, —NR9S(O2)R8, —S(O)2NR9C(O)R6, aryloxy or arylalkyl, wherein the aryl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, aryloxy and arylalkyl may be optionally substituted with 0-3 R1b;
• R1b, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH2, —CN, —NO2, —C(═O)OH, —C(═O)O(CR8R8)rR10, —O(CF2)rCF3, —O(CR8R8)rR10, —OH, —SH, —S(CR8R8)rR10, —S(O)3H, —P(O)3H2, —C(═O)NR9R9, —NR9R9, —S(O)2NR9R9, —NR9S(O)2(CF2)rCF3, —C(═O)NR9S(O)2R6, —S(O)2NR9C(═O)OR6, —S(O)2NR9C(═O)NR9R9, —C(═O)NR9S(O)2(CF2)rCF3, —C(═O)(CR8R8)rR10, —NR9C(═O)H, —NR9C(═O)(CR8R8)rR10, —OC(═O)(CR8R8)rR10, —C(═NR14)NR9R9, —NHC(═NR14)NR14R14, —S(═O)(CR8R8)rR10, —S(O)2(CR8R8)rR10, —NR9C(═O)OR9, —NR9S(O2)R8, aryloxy or arylalkyl;
• R3a and R3b, at each occurrence, are independently hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkylalkyl, or arylalkyl, wherein the alkyl may be substituted with —OH;
• R4, at each occurrence, is F, —OH or alkyl;
• or any two alkyl R4's attached to the same carbon atom may form a 3- to 6-membered ring, which optionally may contain 1-4 heteroatoms selected from N, O, and S;
• R5 is hydrogen, halo, —CN or —Oalkyl;
• R5a is hydrogen, halo, —CN or —Oalkyl;
• R5b is hydrogen, halo, —CN or —Oalkyl;
• provided that R5, R5a and R5b are not all hydrogen;
• R6, at each occurrence, is independently alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl;
• R8, at each occurrence, is independently hydrogen or alkyl;
• R9, at each occurrence, is independently hydrogen, alkyl, cycloalkyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl, wherein the aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl may be optionally substituted with 0-5 R9a, and the heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl contain 1-4 heteroatoms selected from N, O, and S;
• R9a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH2, —CN, —NO2, —C(═O)OH, —C(═O)O(CR8R8)rR14, —O(CF2)rCF3, —O(CR8R8)rR14, —OH, —SH, —S(CR8R8)rR14, —S(O)3H, —P(O)3H2, —C(═O)NR14R14, —NR14R14, —S(O)2NR14R14, —NR14S(O)2(CF2)rCF3, —C(═O)NR14S(O)2R6, —S(O)2NR14C(═O)OR6, —S(O)2NR14C(═O)NR14R14, —C(═O)NR14S(O)2(CF2)rCF3, —C(═O)(CR8R8)rR14, —NR14C(═O)H, —NR14C(═O)(CR8R8)rR14, —OC(═O)(CR8R8)rR14, —C(═NR14)NR14R14, —NHC(═NR14)NR14R14, —S(═O)(CR8R8)rR14, —S(O)2(CR8R8)rR14, —NR14C(═O)OR8, —NR14S(O2)R8, aryloxy or arylalkyl;
• R10, at each occurrence, is independently selected from alkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl, wherein the alkyl, aryl, arylalkyl, heterocyclyl or heterocyclylalkyl may be optionally substituted with 0-3 R10a, and the heterocyclyl and heterocyclylalkyl contain 1-4 heteroatoms selected from N, O, and S;
• R10a, at each occurrence, is independently selected from alkyl, haloalkyl, aryl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl heterocyclylalkyl, halo, —NH2, —CN, —NO2, —C(═O)OH, —C(═O)O(CR8R8)rR14, —O(CF2)rCF3, 0(CR8R8)rR14, —OH, —SH, —S(CR8R8)rR14, —S(O)3H, —P(O)3H2, —C(═O)NR14R14, —NR14R14, —S(O)2NR14R14, —NR14S(O)2(CF2)rCF3, —C(═O)NR14S(O)2R6, —S(O)2NR14C(═O)OR6, —S(O)2NR14C(═O)NR14R14, —C(═O)NR14S(O)2(CF2)rCF3, —C(═O)(CR8R8)rR14, —NR14C(═O)H, —NR14C(═O)(CR8R8)rR14, —OC(═O)(CR8R8)rR14, —C(═NR14)NR14R14, —NHC(═NR14)NR14R14, —S(═O)(CR8R8)rR14, —S(O)2(CR8R8)rR14, —NR14C(═O)OR8, —NR14S(O2)R8, aryloxy or arylalkyl;
• R14, at each occurrence, is independently selected from hydrogen, alkyl, cycloalkyl or phenyl;
• m is 0-2;
• and
• r is 0-5;
• with the following proviso:
• excluding a compound of the following structure: