Methods of treating and preventing Alzheimer's disease
OwnerZhi-Gang Jiang, Hossein Ghanbariinventors
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Abstract
The present invention relates to methods of treating or preventing the progression of Alzheimer's disease, by administering to a patient in need thereof certain thiosemicarbazone compounds. More particularly, the present invention relates to methods of preventing or treating neuronal damage and neuronal cell death occurring as a result of cellular insult of an amyloid-beta peptide. An example of such a thiosemicarbazone is 3-aminopyridine-2-carboxaldehyde thiosemicarbazone (PAN-811).
Claims12
A method of ameliorating the progression of Alzheimer's disease, comprising treating or preventing neuronal damage due cellular insult by amyloid-beta by administering to a subject in need thereof a therapeutically effective amount of a compound of Formula I, or a pharmaceutically acceptable salt or prodrug thereof:
- where HET is a 5 or 6 membered heteroaryl residue having 1 or 2 heteroatoms selected from N and S, and optionally substituted with an amino group;
- and R is H or C1-C4- alkyl,
- whereby the compound provides protection of neurons from the affects of amyloid-beta.
Dependencies are inferred from the claim text.