Tricyclic derivatives or pharmaceutically acceptable salts thereof, their preparations and pharmaceutical compositions containing them

A tricyclic derivative represented by the following <Formula 1> or pharmaceutically acceptable salts thereof.

• (Wherein,
• (1) R1 is -T1-B3;
• in which T1 is —X1—, —X1—C(X2)—, —N(R5)—, —N(R5)C(X2)—, —N(R5)S(O)n1-, —N(R5)C(O)—X3— or —N(R5)C(X1)NH—, in that X1 and X2 are each O or S, R5 is each H or C1˜C5 alkyl group, n, is an integer of 1˜2;
• and B1 is selected from a group consisting of following (a)˜(j),
• Wherein, R6 and R8 are each H, halogen, hydroxy, C1˜C3 alkoxy, amino, nitro, cyano or C1˜C3 lower alkyl group;
• R7 and R9 are each independently halogen, hydroxy, mercapto, 13 ONO, —ONO2 or SNO, in which R7 and R9 are same or different;
• is C5˜C6 membered saturated or unsaturated heterocyclic ring containing 1-2 of hetero atom, in which the hetero atom is selected from a group consisting of O, S and N, preferably,
• more preferably, C1 (pyridyl group) substituted at position 2 and 6 or position 2 and 5, C7 (pyrrolyl group) substituted at position 2 and 5 or position 2 and 4, C11 (thiophenyl group) or C12 (furanyl group);
• Z1 is C1˜C10 straight-chain or branched-chain alkyl group, preferably C2˜C5 straight-chain or branched-chain alkyl group or cycloalkyl group having substituent;
• Z2 and Z3 are each independently H or methyl group, in which Z3 is H when Z2 is methyl group, Z2 is H when Z3 is methyl group;
• T2 is —X1— or —X1—C(X2)—, in that X1 and X2 are each independently O or S;
• B2 is selected from a group consisting of said (a), (b), (c), (d) or (e);
• n2 is an integer of 0˜3, n3 is an integer of 0˜5,n4 is an integer of 1˜5, n5 and, n6 are each independently an integer of 1˜6;
• (2) R2 and R3 are each independently H, —PO3H2, phosphonate, sulfate, C3˜C7 cycloalkyl, C2˜C7 alkenyl, C2˜C7 alkynyl, C1˜C7 alkanoyl, C1˜C7 straight-chain or branched-chain alkyl or sugar, in which sugar is a monosaccharide such as glucuronyl, glucosyl or galactosyl;
• (3) R4 is OCH3, SCH3 or NR10R11 , in which R10 and R11 are each independently H or C1-5 alkyl;
• (4) X is O or S.)