2-carbamide-4-phenylthiazole derivatives, preparation thereof and therapeutic use thereof

A compound of formula (I):

• wherein
• R1 is selected from the group consisting of H, halogen, (C1-C8)alkyl, trifluoro (C1-C4)alkyl, —OH, —O—(C1-C8)alkyl, —O-trifluoro(C1-C8)alkyl, —O—(C3-C10) cycloalkyl-(C1-C8)alkyl, —O—(C3-C10) cycloalkyl, —O—CH2—CH═CH2 and (C1-C4)alkylthio;
• R2 is selected from the group consisting of H, halogen, —OH, (C1-C8)alkyl, trifluoro(C1-C4)alkyl, perfluoro(C1-C4)alkyl, (C3-C10)cycloalkyl, -0-(C1-C8)alkyl, —O—(C3-C10) cycloalkyl (C1-C8)alkyl, —O—(C3-C10) cycloalkyl, —O—CH2—CH═CH2 and (C3-C8)cycloalkyl(C1-C8)alkyl;
• Y represents a hydrogen atom or a halogen;
• R3 represents:
• a1) a group of formula —(CH2)p-A
• in which p represents 0, 1, 2, 3 or 4, and:
• when p represents 2, 3 or 4, A represents a group of formula:
• in which R6 is selected from the group consisting of H, F, (C1-C4)alkyl, —(CH2)nOH, —(CH2)nO(C1-C4)alkyl and —(CH2)nNR4R5, where n represents 0, 1 or 2, and R4 and R5 represent, independently of one another, a hydrogen atom, or a (C1-C8)alkyl, —CO(C1-C4)alkyl or —CO—O-(C1-C8)alkyl group;
• or, when p represents 1, 2, 3 or 4, A represents a group of formula:
• in which R7 is selected from the group consisting of H, (C1-C8)alkyl, —CO—(C1-C8)alkyl, benzyl, —CO—O—(C1-C8)alkyl, —CO—O-benzyl, —CO-phenyl, —CO-heteroaryl, —CO—(C3-C10)cycloalkyl, —SO2—(C1-C8)alkyl, —SO2—(C3-C8)cycloalkyl and —SO2-heteroaryl;
• or, when p represents 0, 1, 2, 3 or 4, A represents a group of formula:
• said group being optionally substituted with a (C1-C4)-alkyl group;
• a2) a group of formula —(CH2)p—CO-A
• in which p represents 1, 2, 3 or 4,
• A represents a group of formula:
• —NR4R5,
• in which R4, R5 and R6 are as defined above;
• a3) a group of formula —CO(CH2)p-A
• in which p represents 0, 1, 2, 3 or 4
• when p represents 1, 2, 3 or 4, A represents a group of formula:
• —NR4R5,
• in which R4, R5 and R6 are as defined above;
• or, when p represents 0, 1, 2, 3 or 4, A represents a group of formula:
• in which R7 is as defined above;
• or, when p represents 0, 1, 2, 3 or 4, A represents a group of formula:
• said group being optionally substituted with a (C1-C4)-alkyl group;
• or
• a4) a group -B
• in which B represents a group of formula:
• in which R7 is as defined above;
• a represents 2 or 3;
• or an acid additional salt thereof, or a hydrate or solvate of said compound or said salt.