Solid and crystalline ibandronate sodium and processes for preparation thereof

A crystalline form of ibandronate sodium selected from the group consisting of:

• a) the crystalline form of ibandronate sodium characterized by x-ray reflections at about 4.7, 5.0, 17.2, 18.3 and 19.5±0.2° 2θ;
• b) the crystalline form of ibandronate sodium characterized by x-ray reflections at about 4.8, 9.3, 18.5, 23.1, and 36.1±0.2° 2θ;
• c) the crystalline form of ibandronate sodium characterized by x-ray reflections at about 4.6, 4.8, 5.3, 9.3, and 34.7±0.2° 2θ;
• d) the crystalline form of ibandronate sodium characterized by x-ray reflections at about 4.9, 5.1, 6.0, 20.0, and 36.4±0.2° 2θ;
• e) the crystalline form of ibandronate sodium characterized by x-ray reflections at about 4.7, 9.2, 17.4, 18.4, and 19.9±0.2° 2θ;
• f) the crystalline form of ibandronate sodium characterized by x-ray reflections at about 4.8, 5.7, 17.3, 19.5, and 26.0±0.2° 2θ;
• g) the crystalline form of ibandronate sodium characterized by x-ray reflections at about 4.6, 9.2, 18.3, 19.6, and 25.6±0.2° 2θ;
• h) the crystalline form of ibandronate sodium characterized by x-ray reflections at about 5.0, 5.9, 17.2, 20.0, and 25.9±0.2° 2θ;
• i) the crystalline form of ibandronate sodium characterized by x-ray reflections at about 5.1, 6.1, 17.3, 20.1, and 21.5±0.2° 2θ;
• j) the crystalline form of ibandronate sodium characterized by x-ray reflections at about 5.1, 6.2, 17.3, 19.7, and 20.1±0.2° 2θ;
• k) the crystalline form of ibandronate sodium characterized by x-ray reflections at about 5.0, 6.1, 17.2, 25.7, and 30.9±0.2° 2θ;
• 1) the crystalline form of ibandronate sodium characterized by x-ray reflections at about 4.7, 6.0, 17.2, 26.2, and 31.0±0.2° 2θ;
• m) the crystalline form of ibandronate sodium characterized by x-ray reflections at about 4.9, 6.2, 25.9, 31.0, and 37.1±0.2° 2θ;
• n) the crystalline form of ibandronate sodium characterized by x-ray reflections at about 5.9, 17.1, 19.6, 20.2, and 21.3±0.2° 2θ;
• o) the crystalline form of ibandronate sodium characterized by x-ray reflections at about 6.1, 17.2, 19.6, 20.3, and 21.4±0.2° 2θ;
• p) the crystalline form of ibandronate sodium characterized by x-ray reflections at about 6.1, 17.2, 19.6, 20.1, and 21.5±0.2° 2θ;
• q) the crystalline form of ibandronate sodium characterized by x-ray reflections at about 6.1, 17.3, 19.6, 21.5, and 30.8±0.2° 2θ;
• r) the crystalline form of ibandronate sodium characterized by x-ray reflections at about 6.2, 25.9, 26.7, 31.1, and 37.2±0.2° 2θ;
• s) the crystalline form of ibandronate sodium characterized by x-ray reflections at about 5.3, 6.0, 17.2, 18.7, and 20.0±0.2° 2θ;
• t) the crystalline form of ibandronate sodium characterized by x-ray reflections at about 4.8, 5.1, 5.3, 5.4, and 6.1±0.2° 2θ;
• u) the crystalline form of ibandronate sodium characterized by x-ray reflections at about 6.2, 15.7, 26.3, 32.6, and 35.6±0.2° 2θ.