Novel 2'-C methyl nucleoside derivatives

A compound of Formula II:

• wherein:
• B is selected from the group consisting of:
• V is selected from the group consisting of optionally substituted monocyclic aryl and optionally substituted monocyclic heteroaryl;
• W and W′ are independently selected from the group consisting of —H, methyl, and V, or W and W′ are each methyl, with the proviso that when W is V, then W′ is H;
• Z is selected from the group consisting of —H, —OMe, —OEt, phenyl, C1-C3 alkyl, —NR42, —SR4, —(CH2)p—OR6, —(CH2)p—SR6 and —OCOR5;
• or
• together V and Z are connected via an additional 3-5 atoms to form a cyclic group, optionally containing 1 heteroatom, that is fused to an aryl group at the beta and gamma position to the O attached to the phosphorus;
• or
• together Z and W are connected via an additional 3-5 atoms to form a cyclic group, optionally containing one heteroatom;
• or
• together W and W′ are connected via an additional 2-5 atoms to form a cyclic group;
• R4 is C1-C4 alkyl;
• R5 is selected from the group consisting of C1-C4 alkyl, monocyclic aryl, and monocyclic aralkyl;
• and
• R6 is C1-C4 acyl;
• R7 and R8 are independently selected from the group consisting of hydrogen, C1-C4 acyl, C1-C4 alkoxycarbonyl, and a naturally-occurring L-amino acid connected via its carbonyl group to form an ester;
• or
• together R7 and R8 form a cyclic carbonate;
• R9 is selected from the group consisting of amino, azido, —N═CHN(R4)2, —NHC(O)R4, and —NHC(O)OR4;
• and
• R10 is selected from the group consisting of OR6, halogen, and H;
• or a pharmaceutically acceptable salt thereof.

A compound of Formula VII:

• wherein B is selected from the group consisting of:
• X is selected from the group consisting of NH2, NHCH3, N(CH3)2, OCH3, SCH3, OH, and SH;
• Y and Y′ are independently O or NH;
• R14 is independently selected from the group consisting of H and NH2;
• the heterocyclic base B may be further substituted at any position on the heterocyclic base B with a substituent of a molecular weight of less than 150 and selected from the group consisting of halogen, alkyl, alkenyl, alkynyl, aryl, alkaryl, cycloalkyl, acyl, and alkoxy, and wherein said substituents may be coupled to the 6-position of the heterocyclic base via a carbon, sulfur, oxygen, or selenium;
• V, W, and W′ are independently hydrogen, alkyl, alkenyl, alkynyl, aryl, alkaryl, each of which is optionally substituted;
• and
• Z is hydrogen, CHWOH, CHWOCOW′, SW, or CH2aryl.