Methods of treating proteinuria by reducing double-stranded dna antibodies
OwnerMatthew LINNIKinventor
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Abstract
The invention provides methods of treating proteinuria in an individual such as human by administering an effective amount of an agent that reduces the level of anti-dsDNA antibodies (such as a dsDNA epitope as in the form of an epitope-presenting carrier or an epitope-presenting valency platform molecule like LJP 394) to the individual. The invention also provides methods of determining responsiveness of the individual to (or selecting an individual for continuing) treatment of an agent that reduces anti-dsDNA antibodies by determining reduction of proteinuria after a certain period of time upon initiation of the treatment.
Claims55
A method of treating proteinuria in an individual having systemic lupus erythematous (SLE) comprising administering an effective amount of an agent which reduces anti-double stranded DNA antibodies in the individual, wherein proteinuria is reduced and wherein the individual is human.
A method of selecting an individual suitable for continued treatment with an agent that reduces anti-dsDNA antibodies, comprising:
- a) administering to the individual an effective amount of the agent for a certain period of time;
- b) measuring reduction of proteinuria at the end of the period, wherein a reduction of proteinuria is indicative that the individual is suitable for continued treatment;
- and
- c) selecting the individual who exhibits responsiveness to the treatment with the agent for further treatment, wherein the individual is human.
A method of treating proteinuria in an individual having SLE comprising:
- (a) assessing proteinuria level in the individual prior to the treatment, wherein the individual is selected for treatment on the basis of proteinuria level;
- and
- (b) administering to said selected individual an effective amount of an agent which reduces anti-double stranded DNA antibodies in the individual, wherein the individual is human.
Dependencies are inferred from the claim text.