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US 2007/0179096 A1Published application
Pharmaceutical Formulation
AssigneeNovo Nordisk A/S
InventorsSoren Bjorn, Hans Sorensen, Peter Langballe, Silke Larsen, Kristen Ebbehoj, Birthe Hamsen
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Abstract
The invention relates to aqueous pharmaceutical formulations comprising human growth hormone, histidine, poloxamer, phenol, and mannitol.
Claims2
An aqueous pharmaceutical formulation comprising a) about 1 mg/ml to about 15 mg/ml of human growth hormone (hGH), b) histidine in an amount of about 0.05-about 0.5 mg per mg hGH, c) Poloxamer 188 in an amount of about 0.1-about 2 mg per mg hGH, d) mannitol in an isotonicity conferring amount, and e) phenol in an amount that confers a preservative effect, wherein the formulation has a pH of about 6.0-about 6.3.
Dependencies are inferred from the claim text.