Method of Enhancing Neural Stem Cell Proliferation, Differentiation, and Survival Using Pituitary Adenylate Cyclase Activating Polypeptide (PACAP)
AssigneeStem Cell Therapeutics Inc.
InventorsShigeki Ohta, Samuel Weiss
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Abstract
The present invention relates to a method of increasing the number and/or differentiation of neural stem cells and/or neural stem cell progeny using pituitary adenylate cyclase-activating polypeptide (PACAP). In a preferred embodiment, additional growth factors are also utilized. The present invention can be practiced in vivo and in vitro, rendering it useful for the treatment of neurodegenerative disease and other neural trauma.
Claims59
A method for increasing neural stem cell or neural stem cell progeny number comprising adding pituitary adenylate cyclase-activating polypeptide (PACAP) to multipotent neural stem cells in an amount effective to increase neural stem cell or neural stem cell progeny number.
A method of increasing the number of neural stem cells or neurospheres in a culture comprising adding pituitary adenylate cyclase-activating polypeptide (PACAP) to a neural stem cell culture to increase the number of neural stem cells or neurospheres generated from the neural stem cell culture.
A method of enhancing differentiation of neural stem cells in a subject comprising administering pituitary adenylate cyclase-activating polypeptide (PACAP) to the subject in an amount sufficient to enhance differentiation of neural stem cells.
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