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US 2007/0179090 A1Published application
G protein coupled receptor agonists and antagonists and methods of activating and inhibiting G protein coupled receptors using the same
AssigneeTufts Medical Center, Inc.
InventorsAthan Kuliopulos, Lidija Covic
Life of this patent
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Abstract
The invention relates generally to G protein coupled receptors and in particular to agonists and antagonists of G protein receptors and methods of using the same.
Claims22
1-102. (canceled)
A chimeric polypeptide, said chimeric polypeptide comprising:
- a) a first domain consisting essentially of a first intracellular loop (i1 loop) or a fragment thereof of a G protein coupled receptor (GPCR), and
- b) a second domain, attached to the first domain, wherein said second domain is naturally or non-naturally occurring cell-penetrating, membrane-tethering hydrophobic moiety
- wherein said first domain does not comprise a native extracellular portion of said GPCR and wherein said chimeric polypeptide binds to its cognate GPCR.
107 The chimeric polypeptide of claim 103, where said i1 loop or fragment thereof comprises at least 3 contiguous amino acid residues of the first intracellular loop.
A chimeric polypeptide, said chimeric polypeptide comprising:
- a) a first domain comprising an isolated i1 loop or fragment thereof of a protease-activated receptor (PAR), and
- b) a second domain, attached to the first domain, wherein said second domain is palmitate.
Dependencies are inferred from the claim text.