Foggy
AssigneeGenentech, Inc.
InventorsArnon Rosenthal, Su Guo
Life of this patent
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Abstract
The present invention relates to neucleotide and amino acid sequences having homology to the zebrafish transcription elongation factor foggy, and to neuronal formation, to a method of directing the differentiation of neuroprogenitor cells into dopaminergic or serotonergic neurons and to a method of treating disorders characterized by abnormalites in and the activity of dopaminergic and serotonergic neurons.
Claims22
A method of forming dopaminergic neurons by contacting neuroprogenitor cells in vitro with an effective amount of a foggy polypeptide.
A method of forming serotonergic neurons by contacting neuroprogenitor cells in vitro with an effective amount of a foggy polypeptide antagonist.
A method of treating a disorder in a mammal wherein said disorder is characterised by degeneration of dopaminergic neurons, comprising transplanting into said mammal a therapeutically effective amount of neuroprogenitor cells pretreated with an effective amount of a foggy polypeptide.
A method of treating a disorder in a mammal wherein said disorder is characterized by degeneration of serotonergic neurons, comprising transplanting into said mammal a therapeutically effective amount of neuroprogenitor cells pretreated with an effective amount of a foggy polypeptide antagonist.
A composition of matter comprising neuroprogenitor cells and an effective amount of a foggy polypeptide antagonist.
A medical device comprising neuroprogenitor cells and an effective amount of a foggy polypeptide antagonist.
Dependencies are inferred from the claim text.