Modulation of rhamm-caveolin/lipid raft interactions to affect development, responses to tissue injury, angiogenesis, tumorigenesis, metastasis and growth factor/cytokine responses
OwnerRashmin Savaniinventor
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Abstract
Compositions and methods for identifying agents which modulate RHAMM-mediated biological activities are provided. Also disclosed are methods for inhibiting exacerbation of certain injuries via regulation of RHAMM-mediated cellular signaling.
Claims16
A method for identifying agents which modulate RHAMM:Caveolin:Lipid raft meditated interactions comprising:
- a) providing cells which express RHAMM;
- b) placing cells under conditions known to alter RHAMM expression level or cellular localization;
- c) incubating the cells of b) in the presence and absence of said agent;
- and
- d) determining whether said agent alters RHAMM expression level or localization relative to cells which are not contacted with said agent, thereby identifying agents which modulate RHAMM:Caveolin:Lipid raft interactions.
A method of inhibiting escalation of a tissue injury, said method comprising treating a mammal at an onset of the tissue injury with an agent which inhibits RHAMM:caveolin interaction.
A method of inhibiting escalation of a tissue injury, said method comprising treating a mammal at the onset of the tissue injury with an agent which inhibits interaction between RHAMM and hyaluronan (HA) oligosaccharides.
Dependencies are inferred from the claim text.