Consensus/ancestral immunogens
AssigneesDuke University, The Regents of the University of California, University of Alabama at Birmingham Research Foundation
InventorsBarton Haynes, Feng Gao, Bette Korber, Beatrice Hahn, George Shaw, Denise Kothe, Ying Ying Li, Julie Decker, Hua-Xin Liao
Life of this patent
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Abstract
The present invention relates, in general, to an immunogen and, in particular, to an immunogen for inducing antibodies that neutralizes a wide spectrum of HIV primary isolates and/or to an immunogen that induces a T cell immune response. The invention also relates to a method of inducing anti-HIV antibodies, and/or to a method of inducing a T cell immune response, using such an immunogen. The invention further relates to nucleic acid sequences encoding the present immunogens.
Claims12
1-96. (canceled)
An isolated protein comprising the sequence of amino acids set forth in FIG. 1A, FIG. 6C, FIG. 6D, FIG. 20C, FIG. 20D, FIG. 26A, FIG. 28B, FIG. 29B, FIG. 30B, FIG. 31B, FIG. 32B, FIG. 33B, FIG. 34B, FIG. 35B, FIG. 36B, FIG. 37B, or FIG. 38B.
A nucleic acid comprising a nucleotide sequence encoding:
- CON6 HIV gp160 protein,
- subtype C ancestral HIV envelope protein,
- subtype C consensus HIV envelope protein,
- subtype C consensus HIV gag protein,
- subtype C consensus HIV nef protein,
- Group M consensus HIV envelope protein,
- subtype A consensus HIV envelope protein,
- Group M consensus HIV gag protein,
- Group M consensus HIV pol protein,
- Group M consensus HIV nef protein,
- subtype C consensus HIV pol protein,
- subtype B consensus HIV gag protein, or
- subtype B consensus HIV envelope protein
- wherein said nucleotide sequence comprises codons optimized for expression in human cells.
An isolated protein comprising a CF or CFI form of the amino acid sequence set forth in any one of FIGS. 39A-127A.
A nucleic acid comprising the nucleotide sequence set forth in any one of FIGS. 39B-62B, FIGS. 63B-84B, FIG. 65D, FIG. 67D, FIG. 68D, FIGS. 85B-106B, FIG. 88D, FIG. 90D, FIG. 92D, FIGS. 107B-127B, FIG. 109D, FIG. 111D and FIG. 112D.
Dependencies are inferred from the claim text.