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US 2007/0178559 A1Published application
Platelet promoting protein and the usage thereof
OwnerPeilin Xu, Yichen Ge +1inventors
InventorsPeilin Xu, Yichen Ge, Yan Yang
Life of this patent
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Abstract
The present invention discloses a protein that has strong affinity to thrombopoietin receptor (C-MPL) and the nucleotide sequences of the protein. The protein is capable of increasing the numbers of platelets and enhancing the blood clotting in vivo and is named as platelet promoting protein (PPP). The protein and its nucleotide sequences can be used for the treatment of blood diseases including thrombocytopenia.
Claims10
An isolated human-derived protein, having an amino acid sequence of:
- MGGEQEEERF DGMLLAMAQQ HEGGVQELVN TFFSFLRRKT
- DFFIGGEEGM AEKLITQTFS HHNQLAQKTR REKRARQEAE
- RREKAERAAR LAKEAKSETS GPQIKELTDE EAERLQLEID
- QKKDAENHEA QLKNGSLDSP GKQDTEEDEE EDEKDKGKLK
- PNLGNGADLP NYRWTQTLSE LDLAVPFCVN FRLKGKDMVV
- DIQRRHLRVG LKGQPAIIDG ELYNEVKVEE SSWLIEDGKV
- VTVHLEKINK MEWWSRLVSS DPEINTKKIN PENSKLSDLD
- SETRSMVEKM MYDQRQKSMG LPTSDEQKKQ EILKKFMDQH
- PEMDFSKAKF N;
- or a derivative thereof with a function of increasing the numbers of blood platelets.
7 more elements
Dependencies are inferred from the claim text.