Mammalian T-type calcium channels
AssigneeNeuromed Pharmaceuticals Ltd.
InventorsTerrance Snutch, David Baillie
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Abstract
Sequences and partial sequences for three types of mammalian (human and rat sequences identified) T-type calcium channel subunits which we have labeled as the α1G, α1H and α1I subunits are provided. Knowledge of the sequence of these calcium channel permits the localization and recovery of the complete sequence from human cells, and the development of cell lines which express the novel calcium channels of the invention. These cells may be used for identifying compounds capable of acting as agonists or antagonists to the calcium channels.
Claims20
An isolated recombinant DNA molecule which comprises an expression cassette wherein said expression cassette comprises a nucleotide sequence encoding a T-type calcium channel α1H subunit, said encoding sequence operably linked to control sequences to effect its expression;
- wherein said α1H subunit has an amino acid sequence at least 95% identical to SEQ ID NO:
- 26.
An isolated nucleic acid molecule which comprises a nucleotide sequence encoding a T-type calcium channel α1H subunit or its full-length complement, wherein said α1H subunit has an amino acid sequence at least 95% identical to SEQ ID NO:
- 26.
Dependencies are inferred from the claim text.