Novel Cytokine Receptors and Nucleic Acids Encoding the Same
AssigneeGenentech, Inc.
InventorsAudrey Goddard, Paul Godowski, Austin Gurney, Colin Watanabe, William Wood
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Abstract
The present invention is directed to novel cytokine receptors having sequence similarity to AF18497_1 and to nucleic acid molecules encoding those cytokine receptors. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
Claims24
An isolated nucleic acid molecule which comprises DNA having at least 80% sequence identity to (a) a DNA molecule encoding a PRO19598 polypeptide comprising the sequence of amino acid residues from 1 or 21 to about 262 of FIG. 2 (SEQ ID NO:2), or the complement of the DNA molecule of (a).
An isolated PRO19598 polypeptide comprising an amino acid sequence comprising at least 80% sequence identity to the sequence of amino acid residues from 1 to 21 to about 262 of FIG. 2 (SEQ ID NO:2).
An antibody which specifically binds to (a) the polypeptide of SEQ ID NO:2 or (b) the polypeptide of SEQ ID NO:2, lacking its associated signal peptide.
A method of detecting a polypeptide designated as PRO3301 in a sample suspected of containing a PRO3301 polypeptide, said method comprising contacting said sample with a polypeptide designated herein as PRO19598 and determining the formation of a PRO3301/PRO19598 polypeptide conjugate insaid sample, wherein the formation of said conjugate is indicative of the presence of a PRO3301 polypeptide in said sample.
A method of detecting a polypeptide designated as PRO19598 in a sample suspected of containing a PRO19598 polypeptide, said method comprising contacting said sample with a polypeptide designated herein as PRO3301 and determining the formation of a PRO3301/PRO19598 polypeptide conjugate in said sample, wherein the formation of said conjugate is indicative of the presence of a PRO19598 polypeptide in said sample.
A method of modulating at least one biological activity of a cell that responds to a polypeptide designated as PRO3301, said method comprising contacting said cell with a PRO19598 polypeptide, whereby said PRO19598 polypeptide binds to said PRO3301 polypeptide, thereby modulating at least one biological activity of said cell.
A method of antagonizing a PRO3301 polypeptide, the method comprising allowing the PRO3301 polypeptide to bind to a PRO19598 polypeptide, thereby antagonizing said PRO3301 polypeptide.
A method for detecting the presence of tumor in a mammal, said method comprising comparing the level of expression of a PRO3301 polypeptide in (a) a test sample of cells taken from said mammal and (b) a control sample of normal cells of the same cell type, wherein a higher level of expression of said PRO3301 polypeptide in the test sample as compared to the control sample is indicative of the presence of tumor in said mammal.
Dependencies are inferred from the claim text.