ME-5, ME-2, and EPP2: human protein antigens reactive with autoantibodies present in the serum of women suffering from endometriosis
OwnerA.Said Shami, Bruce Campbell +2inventors
InventorsA.Said Shami, Bruce Campbell, Dennis Sustarsic, Niver Sahakian
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Abstract
Three human endometrial antigens, ME-5, ME-2 and EPP2, and combination thereof have been discovered that are the targets of antibodies present in the serum of women suffering from endometriosis. These protein products and the human antibodies reactive with them are used as tools for diagnostic assays that monitor patients with the disease of endometriosis.
Claims43
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A method for detecting a ME-2 polypeptide (SEQ ID NO:6) in a sample, comprising the steps of:
- (a) contacting the sample with an antibody that specifically binds an epitope of the ME-2 polypeptide and
- (b) detecting specific binding between the antibody and ME-2 polypeptide;
- whereby specific binding provides a detection of ME-2 polypeptide in the sample.
A method for diagnosing endometriosis in a human subject comprising the steps of:
- (a) detecting a test amount of an antibody that specifically binds to ME-2 polypeptide (SEQ ID NO:6) or a peptide comprising an epitope of ME-2 in a sample from the subject;
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- (b) comparing the test amount with a normal range of the antibody in a control sample from a subject who does not suffer from endometriosis,
- whereby a test amount above the normal range provides a positive indication in the diagnosis of endometriosis.
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