Use of protein profiles in disease diagnosis and treatment
OwnerStilianos Kountakis, Bao-Ling Adaminventors
Life of this patent
Estimating the term…
Abstract
Disclosed are methods, systems, and articles of manufacture for using proteomics for the diagnosis and treatment of diseases. The methods may be used to diagnose a particular disease or disease subtype. For example, the methods may be used to diagnose chronic rhinosinusitis and diseases related thereto.
Claims19
A method for identifying a disease in a subject comprising:
- (a) generating a protein profile comprising at least one defined protein from a sample isolated from the subject;
- (b) comparing the protein profile for the subject to a reference protein profile;
- and
- (c) correlating the protein profile with a disease of interest.
A method for identifying proteins that are expressed as a result of a developing a disease of interest comprising:
- (a) isolating a plurality of samples from a plurality of subjects that exhibit the symptoms of the disease of interest;
- (b) analyzing a protein profile obtained from each of the samples;
- and
- (c) correlating expression of at least one individual protein identified in at least some of the protein profiles to the disease of interest.
A system for determining a diagnosis and/or prognosis of a specific disease in a subject comprising:
- (a) a component for generating a protein profile comprising at least one defined protein from a sample isolated from a subject;
- (b) a component for comparing the protein profile for the subject to a reference protein profile;
- and
- (c) a component for correlating the protein profile with a disease of interest.
An article of manufacture comprising a protein profile captured on a medium, wherein the protein profile comprises at least one protein that is correlated with the development and/or propagation of a disease of interest in a subject.
Dependencies are inferred from the claim text.